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Digestive Enzymes

Trying to find the best digestive enzyme supplement? We found major differences in their strengths. See our tests, comparisons, and Top Picks. Also learn about pancreatin, proteases including bromelain and papain, lipase, amylase and more. Get the evidence for use for digestive symptoms and other conditions, as well side-effects and cautions.

Digestive Enzymes Review

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CL Answer

Is bromelain a good alternative to NSAIDs, like ibuprofen, for muscle or joint pain?

Do bromelain supplements have benefits? Learn more about its safety, and if it is a good alternative to NSAIDs like ibuprofen.

Bromelain Supplements Top View

CL Answer

Which supplements are best for seasonal allergies?

Find out which supplements are best for allergies and can help reduce seasonal allergy symptoms, including bromelain, curcumin, vitamin D, and CLA.

Supplements for Seasonal Allergies -- Woman Outside Sneezing

CL Answer

Do any supplements help for ulcerative colitis?

Find out what supplements & vitamins can help with ulcerative colitis, such as VSL#3, curcumin, aloe or boswellia.

Woman Grabbing Stomach Due To Abdominal Discomfort

Product Review

Protein Powders, Shakes, and Meal Replacements Review

Find Out Which Protein Products Passed or Failed Our Tests

CL Answer

I take warfarin (Coumadin), an anticoagulant drug. Are there supplements I should avoid, or be taking, due to this drug?

Find out which supplements should be avoided when taking blood thinners (anticoagulants) like warfarin (Coumadin), including vitamin K, St. John's wort, and curcumin.

Warfarin Supplement Interactions -- bottle of pink warfarin tablets

CL Answer

Are there any supplements I should avoid when taking an antibiotic? Are there any that may be helpful?

Find out which supplements can negatively interact with antibiotics, including vitamin K, magnesium, and calcium, and which may be helpful when taking antibiotics.

Supplement Interactions With Antibiotics -- man reading prescription bottle instructions

CL Answer

Do any supplements help prevent or treat a cold?

Are there supplements that can help prevent or treat cold symptoms? Learn more about zinc, probiotics, vitamin C and more.

Supplements for Colds: Zinc, Echinacea & More -- Couple with cold, sitting on couch blowing their noses

CL Answer

Do any supplements help treat or reduce the pain of plantar fasciitis (heel pain)?

Plantar fasciitis causing heel pain has, in rare cases, been reported as a symptom of vitamin D deficiency. Other supplements that have been proposed to help include vitamin C, zinc, curcumin (from turmeric), bromelain, collagen and glucosamine. Find out what the evidence shows, and what other treatments may help.

Supplements for Plantar Fasciitis -- Woman With Heel Pain

CL Answer

Which supplements help for osteoarthritis of the hip?

Supplements for hip pain and osteoarthritis, such as SAMe, ginger and collagen, may help or reduce pain.

Woman Holding Hip from Pain

Product Review

Joint Health Supplements Review (Glucosamine, Chondroitin, MSM, Boswellia, Collagen and Turmeric)

One-Third of Joint Health Supplements Failed to Pass Our Tests. See Which Passed or Failed, and our Top Picks.

Review of Supplements for Joint Pain

Clinical Update

3/24/2023

Bromelain Supplements on Amazon Fail Tests

Only four of 20 brands of bromelain purchased on Amazon provided the enzyme activity expected from their labels, three of which had no detectable enzyme activity, according to a recent report. For details by brand, see the Quality Concerns section of our Digestive Enzyme Supplements Review, which includes our Top Picks among digestive enzyme products.

CL Answer

Which supplements help with arthritis?

Learn more about supplements for joint health, including products such as Wobenzym and Zyflamend and ingredients such as collagen, curcumin, glucosamine and chondroitin, hyaluronic acid, magnesium, omega-3 fatty acids, palmitoylethanolamide (PEA), SAMe, and others.

Supplements for Osteoarthritis and Rheumatoid Arthritis -- Women With Arthritic Hands

Product Review

Olive Leaf Extract Supplements Review

Learn What Olive Leaf Does and the Best Brands

Product Review

Lion's Mane and Chaga Supplements Review

Read Labels Carefully -- Many Can Mislead

Lion's Mane and Chaga Supplements tested by ConsumerLab.com

Product Review

Electrolytes & Sports Drinks Review

See Which Sports Drinks, Powders, and Pills Deliver the Right Electrolytes

Product Review

Lavender and Tea Tree Essential Oils Review

Oils Tested for Authenticity and Purity

CL Answer

What are the health benefits of serrapeptase?

Serrapeptase is a proteolytic enzyme. Learn more about its health effects, including whether evidence supports its use for pain, inflammation, and heart health.

Serrapeptase for Inflammation and Pain

Product Review

B Vitamin Supplements Review (B Complexes, B6, B12, Biotin, Folate, Niacin, Riboflavin & More)

See Which B Vitamins Are ConsumerLab's Top Picks!

Review of B Vitamin Supplements

Product Review

Multivitamin and Multimineral Supplements Review

Best Multivitamins In 2023 -- Caution with Gummies

Clinical Update

9/21/2021

Enzyme Supplements for Eye Floaters?

Can enzyme supplements (bromelain, papain and ficin) reduce eye floaters? Find out what a recent study suggests in the What They Do section of our Digestive Enzyme Supplements Review.

Also see our answer to the question: Do any supplements help prevent or reduce eye floaters?

CL Answer

What is Skinny Fiber and does it really work? I see that glucomannan is a key ingredient. What is that?

Learn more about Skinny Fiber, including its key ingredient glucomannan, evidence from clinical studies, dosage info, and safety.

Skinny Fiber

CL Answer

Do any supplements help with gum disease or periodontitis?

Supplements for healthy gums may help with gum disease or periodontitis. Learn more about omega fatty acids, lycopene, and probiotics.

Smiling Woman Taking White Supplement with Glass of Water

CL Answer

After taking a curcumin supplement, I started getting chronic diarrhea which went away when I stopped taking it. Can curcumin supplements cause diarrhea?

Learn more about the side effects of curcumin supplements, including diarrhea and other gastrointestinal discomfort.

Turmeric and Diarrhea

CL Answer

Are there supplements I should avoid when taking apixaban (Eliquis) or similar blood thinner drugs like Xarelto?

Learn about supplement interactions with apixaban (Eliquis), rivaroxaban (Xarelto) and other blood thinner drugs in the direct factor Xa inhibitors class.

Eliquis Supplement Interactions -- box of Eliquis

Product Review

Vitamin D Supplements Review (Including Calcium, Magnesium, Boron, and Vitamin K)

Find the Best Vitamin D Supplement with the Right Dose

Product Review

Fruits, Veggies, and Other Greens Supplements Review (Including Spirulina and Chlorella)

Avoid Lead in Greens, Problems with Pills, and Don't Give Up Eating Whole Foods.

Greens Review Oct 2023

Product Review

Nattokinase Supplements Review

Choose the Best Nattokinase Supplement. CL Tests Reveal Which Nattokinase Suppplements Provide the Best Quality & Value.

Nattokinase Supplements Tested by Consumerlab.com

CL Answer

Do any supplements help prevent or reduce eye floaters?

Find out eye floaters (vitreous floaters) be treated with supplements like vitamin C, lutein, ginkgo, milk thistle, collagen or hyaluronic acid, or with products such as VitreousHealth.

How to Reduce Eye Floaters With Vitamins & Supplements -- Close-up of an eye

CL Answer

I read that turmeric may be a GI irritant. I have GI problems and wonder if I should avoid turmeric and curcumin?

Find out if turmeric/curcumin supplements can cause gastrointestinal irritability.

Is turmeric a stomach irritant? -- Turmeric Supplement

CL Answer

I recently read that turmeric is only effective if it is combined with black pepper. Is this true?

Find out the best way to take turmeric and curcumin supplements to increase absorption and bioavailability. ConsumerLab.com's answer explains.

Is Turmeric Only Effective with Black Pepper? -- Turmeric Supplement and Black Pepper

Product Review

Zinc Supplements and Lozenges Review

Find the Best Zinc Supplements and Lozenges. Have a Cold? See CL's Top Picks Among Zinc Supplements and Lozenges.

Zinc Supplements and Lozenges Reviewed by ConsumerLab.com

Product Review

Iron Supplements Review (Iron Pills, Liquids and Chews)

See Which Iron Supplements Are CL's Top Picks for Different Needs

Product Review

Vitamin K Supplements Review (Including Calcium, Magnesium, Boron, and Vitamin D)

Should You Take Vitamin K? Beware of Products That Don't Deliver.

CL Answer

What are the health benefits of tart cherry juice?

See the evidence for tart cherry juice health benefits from clinical studies. Find out if tart cherry has anti-inflammatory effects, if it can improve sleep, lower high blood pressure, or help for muscle pain and osteoarthritis.

Tart Cherry Benefits -- glass of cherry juice and two tart cherries

Product Review

Calcium and Bone Health Supplements Review (Including Vitamins D & K, Magnesium and Boron)

See Which Bone Health Supplements Are Top Picks and Which Fail

CL Answer

Which supplements help reduce the risk of colorectal cancer?

Find out which supplements may reduce the risk of colorectal cancer, including folate, fiber, selenium, and vitamin D.

Supplements and Colorectal Cancer Risk -- colon cancer diagnosis form and supplements

Product Review

Magnesium Supplements Review (Including Calcium, Boron, and Vitamins D & K)

Find Out What Magnesium Does, Who Needs It, and Our Top Picks Among Supplements

CL Answer

Which ingredients should toothpastes and other dental products contain, and which should be avoided?

Learn about ingredients you want in your toothpaste, mouthwash and other dental products and which ingredients you may want to avoid.

Toothpaste in the shape of question mark coming out from toothpaste tube

CL Answer

Which supplements and foods help with gout and which may worsen it?

Find out about the effects on uric acid levels and gout of fish and fish oil, coffee, beer, animal meat, milk proteins, vegetable proteins, fructose, lemon juice, tart cherry juice, vitamin A, vitamin C, and niacin

Woman with gout pain rubbing her foot near the big toe

News Release

May 15, 2019

ConsumerLab Tests Reveal Big Differences in Digestive Enzyme Supplements

White Plains, New York, May 15, 2019 — Digestive enzyme supplements can help improve digestion and the absorption of nutrients, and may reduce symptoms of indigestion. But to work, they must provide a certain amount of enzyme activity.

Recalls & Warnings

September 28, 2022

FDA Warns Muscle Sports for Joint Health, Immune & Workout Supplement, Vitamin C, Elderberry, and Other Claims

On September 23, 2022, the FDA issued a warning letter to Muscle Sports Products, LLC following inspection of the company’s websites which found statements about company products, including Join Revolution Capsules, IMMUNITY + Powder, Rhino Rampage PUMPED Capsules, Attack Pre-Workout ...

News Release

February 16, 2011

Some turmeric and curcumin supplements fail quality review -- ConsumerLab.com finds 20% of turmeric supplements selected for review deliver less than 15% of promised compounds

WHITE PLAINS, NEW YORK — FEBRUARY 16, 2011 — Supplements containing the herb turmeric or its key compound, curcumin, have become popular in the U.S. ConsumerLab.com cautioned today that two out of ten turmeric products recently selected for quality testing were found to provide only 7.

Recalls & Warnings

August 29, 2017

FDA Warns Seller of Supplements for Allergies, Joint Pain, Bone Health, and More

On August 16, 2017, the FDA issued a warning letter to Total Nutrition, Inc.

Recalls & Warnings

September 10, 2012

Maker of Concussion Recovery Supplement Warned For Making Drug Claims

On August 28, 2012, the FDA issued a warning letter to Trinity Sports Group, Inc. after a review of the company's websites found statements about Neuro Impact Concussion Response Formula constituted drug claims not permitted on supplements. 

Recalls & Warnings

February 28, 2017

Multivitamin Recalled Due to Allergen Risk

On February 14, 2017, Licata Enterprises issued a recall of all lots of its Supreme One and Theravits 100 multiple vitamins because they contain fish liver oil but is labeled as containing "no common allergens.

Recalls & Warnings

December 16, 2013

Weight Loss Capsules Recalled Due Allergen Risk

On December 13, 2013, Stone Independent Research, Inc. issued recall of one lot of Zanocap Scientific Weight Loss 500 mg capsules because they contain undeclared whey protein, which is derived from milk.

Recalls & Warnings

April 23, 2013

Seller of Digestion, Thyroid and Vitamin D Supplements Warned For Drug Claims

On November 5, 2012, the FDA issued a warning letter to The Women's Health Institute at Texas following a review of the company's various websites which found statements made about Digest + SEB, Iodine Plus 2, and D5000 Vitamin D dietary supplements to be drug claims.

Recalls & Warnings

January 24, 2013

Food for Health Warned for Manufacturing Violations and Drug Claims on Supplements

On October 5, 2012, the FDA issued a warning letter to Food for Health International, LLC following a facility inspection which found the company's products, including Activz brand Vitamin D, Potassium Iodine, Organic Vitamin C, Whole 9 (a fruit and vegetable meal replacement shake) Control and VMA ...

Recalls & Warnings

November 21, 2012

Maker of Blood Pressure, Probiotic, Resveratrol and Hormonal Supplements Warned For Manufacturing Violations and Drug Claims

On November 2, 2012, the FDA issued a warning letter to Atrium, Inc. following a facility inspection which found a number of the company's dietary supplements to be adulterated or promoted as drugs.

Recalls & Warnings

February 13, 2013

Manufacturer of Heart, Multivitamin, Cranberry, and Longevity Supplements Warned For Adulteration and Drug Claims

On January 29, 2013, the FDA issued a warning letter to M.D.R. Fitness Corp. following a facility inspection which found violations of good manufacturing practices which cause the company's products to be adulterated.