Initial Posting: 8/30/2016    Last Update: 8/8/2017
Answer: Lovaza and Epanova may cause increases in liver enzymes and "bad" cholesterol. Lovaza may also increase the frequency of heart rhythm problems. The same side effects would be expected with generic versions of these prescription drugs (which are highly concentrated fish oils) but not necessarily with fish oil supplements that provide lower doses of EPA and DHA. Interestingly, these particular side effects have not been reported with a prescription fish oil that does not contain DHA, but can cause joint pain. For details, see the Concerns and Cautions section of the Fish Oil Supplements Review.