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zuPOO supplement bottle with white background


zuPOO (by Umzu) is marketed as a gut support supplement and colon cleanser that may help with weight loss. It lists 1,270 mg of a proprietary blend of ingredients that includes three stimulant laxatives (ingredients that promote bowel movements by causing muscle contractions in the intestines) — cascara sagrada bark extract, senna leaf powder, and cape aloe (Aloe ferox) leaf extract — as well as fennel seed powder, burdock root powder, bentonite clay, buckthorn bark powder, slippery elm bark powder, milk thistle seed powder, and cayenne red pepper fruit powder.

While these ingredients certainly can clear the gut, they carry significant risks. Sign in as a member for details.

Also see "Which supplements and foods help relieve constipation and which can cause constipation?" for information about other supplements that may be helpful for treating constipation.

For more information about supplements for weight loss, including whether any work and if they are safe, see our Weight Loss Supplements Review, which includes our Top Picks for weight loss supplements.

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