uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.


Person in Pink Shirt Scratching Arm


Histamine intolerance refers to a wide range of symptoms (such as itching, rash, headache, gastrointestinal distress and difficulty breathing) that can be triggered in some people by eating foods rich in histamine (fish, cheese, sausage, wine, and beer) or by taking certain drugs. There is evidence that in some people, symptoms of histamine intolerance could be caused by low activity of the DAO enzyme, which helps to break down histamine in the body. Supplements containing DAO are promoted to help break down histamine to reduce symptoms.

Sign in to the full answer for more information including foods to avoid, studies evaluating DAO supplementation for symptoms of histamine intolerance including hives, gastrointestinal symptoms and migraines, DAO dosage, and which DAO supplements in the U.S. are similar to what has worked in clinical trials.

Join today to unlock all member benefits including full access to all CL Answers and over 1,300 reviews.

Join Now

Join now at

Loading Comments…