uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.


 Indole-3-carbinol (I3C) and Cancer Risk -- bunches of broccoli, cabbage and cauliflower


Studies have shown that high consumption of broccoli and other cabbage-family vegetables is associated with reduced risk of a variety of cancers. This has spurred research into potential anticancer effects of compounds that occur in these vegetables, such as indole-3-carbinol (I3C) and its derivative diindolylmethane (DIM), both of which are sold as supplements.

Preliminary research showed that I3C may benefit women with certain estrogen-sensitive cancers and precancers, such as ovarian cancer and cervical dysplasia, but there is concern that it may also have the potential to increase cancer risk in some situations. DIM, a chemical formed in the body upon ingestion of I3C, has also been studied for people with cancer (breast or prostate cancer) or pre-cancerous conditions (cervical dysplasia), but most clinical studies have shown limited to no benefit.

Sign in for more details, including information about the safety and possible side effects of these supplement ingredients, including the potential risk of clots and stroke.

Join today to unlock all member benefits including full access to all CL Answers and over 1,400 reviews.

Join Now

Join now at

Loading Comments…