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Question: Is it safe to take Bioperine (which contains piperine from black pepper)?
Answer: Piperine (from black pepper) can enhance the absorption or bioavailability of certain compounds, such as curcumin from turmeric. Bioperine is a branded extract of black pepper which is 95% piperine and is commonly included in curcumin supplements, but is also sold separately. Be aware that piperine can interact with many medications and may also have anti-platelet effects. In addition, it may cause gastrointestinal side-effects and, potentially, bleeding, at somewhat higher-than-suggested doses. See the "Concerns and Cautions" for black pepper extract within the Turmeric/Curcumin Supplements Review.