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Metafolin Compared to Folic Acid

Question:
What is Metafolin (5-methylfolate)? I see it in some supplements instead of folic acid. Is it better than folic acid?

Answer:
Supplements have typically provided folic acid as their source of folate -- an essential B vitamin. In 2001 and 2010, respectively, Metafolin and Quatrefolic were approved in the U.S. as sources of folate in supplements. These two ingredients have some advantages compared to folate from foods and folic acid, and they differ somewhat from each other. You can get details about these ingredients in the section on Folate in the B Vitamins Review >>

Products containing Metafolin and Quatrefolic have been tested and reviewed in ConsumerLab.com's Multivitamin Supplements Review >>


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COMMENTS

Delia17620   March 11, 2019
Dr Ben Lynch in his book Dirty Genes explains why folic acid is dangerous because it interferes in cell methylation process while natural folate is essential, hence, folic acid should be banned as supplement. Any comments abut this?

ConsumerLab.com   March 11, 2019
Hi Delia - At moderate doses, folic acid has not been shown to be dangerous, and it is better-absorbed than natural folate from foods. However, folic acid may be dangerous when taken at higher doses than required, while this is not the case with folate from food.


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This CL Answer initially posted on 4/18/2013. Last updated 8/8/2017.
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