Supplements promoted to increase energy, reduce stress and other symptoms caused by "adrenal fatigue" may contain a variety of ingredients, including vitamins and minerals, herbs (such as ashwagandha, ginseng, holy basil, rhodiola, and schisandra), and/or dehydrated adrenal gland tissue from animals (typically from bovine source, i.e., cows). While some of these ingredients have individually been shown to reduce fatigue or symptoms of stress, there is currently little evidence that "adrenal support formulas" do the same or improve adrenal gland function. Additionally, an analysis of popular adrenal support supplements on the market found that all contained small amounts of thyroid and steroid hormones, which could potentially cause adverse effects or interfere with blood test results. See the full answer >>

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April 20, 2019

Can I take Rhodiola and Holy Basil together

April 15, 2018

While no studies fully support the effectiveness of adrenal support supplements, I can say with absolute certainty that they can be extremely effective. I currently take a formula and have tracked its effectiveness through lab work and my adrenals are gradually healing. But not every formula will work for everyone; it is a matter of finding the right one for your individual constitution. For me, I have had tangible results from Apex Energetics Adaptocrine and currently Dr Berg Adrenal & Cortisol Support, which I was initially very skeptical about but it has helped tremendously.
April 19, 2018

Hi Michael - In what way did you find these products helpful? What differences did you notice?

Mary Jo16757
April 23, 2018

I too have had extremely good results with taking adrenal supplements. For me I believe it was the granular extracts that were most helpful. I have taken DSF formula from Nutrition-West and also Vital Nutrients Adrenal Suport. I found these supplements helpful to regain my energy, help me cope emotionally and also help in muscle recovery. I think it is also extremely important for the person with adrenal issues to understand and figure out the source of what is causing stress on the adrenals, be it physical, chemical or emotional. In my case it was both physical (doing too much, not enough sleep) and chemical (food allergies and parasites). It took several years to figure this all out, but the supplements were a life saver through it all. I had a dog with Addison's disease (complete failure of the adrenal glands) and learned the importance of taking care of your adrenals.

December 8, 2019

Michael1672, I would appreciate it if you would comment on which product worked for you. I have (checked via lab) low salivary cortisol and low normal ACTH. I will see an endocrinologist on Friday. However, I did take a low dose 2 mg of pregnenolone for two days. I realize there is little research available on effectiveness but as a PhD in biochemistry/pharmacology, I felt that dose wouldn't hurt and the pathway I sketched out seemed reasonable enough. Lo and behold, severe spine pain from which I have suffered for several years progressively worsening resulting in 18 cortisone injections in one year - not operable. The cortisone injections induced the low cortisol. My hope was that the pregnenolone would goose my adrenal glands and others into doing their job. It has been 5 days and I feel ever so much better. The severe fatigue from low cortisol had me thinking this was it. I would appreciate it if you would share directly the agent that worked for you. Thank you.

December 8, 2019

Thank you for your informative comments.

December 9, 2019

I apologise for this very late reply. Nevertheless, the most positive affect was the ability to get to sleep and not wake throughout the night (that alone can be life changing). I also found a reduction in feelings of anxiety; improved and more level energy; reduced inflammation/join/t pain; and many other tangible effects. Essentially, the result is feeling normal and not tired, wired or in chronic pain.

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