Supplements to Take or Avoid When Using a GLP-1 Drug

Medically reviewed and edited by Tod Cooperman, M.D.

Written by Meredith A. Worthington, Ph.D.

Published October 06, 2025

Answer:

Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications that includes semaglutide (Wegovy, Ozempic, Rybelsus) and tirzepatide (Zepbound, Mounjaro), have become increasingly popular for obesity treatment (Mahrtash, JAMA Intern Med 2025). These medications work by slowing digestion to increase fullness and reduce food cravings. These medications also help control blood sugar levels.

Certain supplements may be helpful when taking a GLP-1 drug, but others should be used with caution or avoided, and it may be important to monitor levels of certain vitamins and minerals.

Sign in as a member for more details. Supplements discussed include calcium, fiber (such as psyllium), iron, potassium, probiotics, protein, turmeric/curcumin, vitamin B-12, and vitamin D, as well as supplements that can affect blood sugar control.

+ — 12 sources

In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article: