Supplements to Take or Avoid When Using a GLP-1 Drug

Answer:

Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications that includes semaglutide (Wegovy, Ozempic, Rybelsus), tirzepatide (Zepbound, Mounjaro), liraglutide (Victoza, Saxenda), and orforglipron (Foundayo), have become increasingly popular for obesity treatment (Mehrtash, JAMA Intern Med 2025). These medications work by slowing digestion to increase fullness and reduce food cravings. These medications also help control blood sugar levels.

Certain supplements may be helpful when taking a GLP-1 drug, but others should be used with caution or avoided, and it may be important to monitor levels of particular vitamins and minerals.

Sign in as a member for more details. Supplements discussed include calcium, fiber (such as psyllium), iron, potassium, probiotics, protein, turmeric/curcumin, vitamin B-12, and vitamin D, as well as supplements that can affect blood sugar control and supplements for hair loss. Also discussed are supplements said to naturally increase GLP-1 levels, such TUDCA, Akkermansia, a branded cayenne pepper (Capsimax), and the sweetener allulose, as well berberbine, which has been touted as "nature's Ozempic." In addition, find out if topical "natural GLP-1" patches and gels are likely to be safe or beneficial.