Which supplements have been shown to be helpful for autism, and which have not?

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Folic Acid for Autism?

Written by Tod Cooperman, M.D.

Updated October 01, 2025 ⓘ

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Answer:

No supplement can treat or cure autism spectrum disorder (ASD), but some supplements may help reduce symptoms such as irritability, tantrums, rule-breaking behavior, aggressive behavior, hyperactivity, and sleep disturbances. There are also supplements that, although touted, do not seem to be beneficial.

Sign in as a member for the evidence around the following supplements: Digestive enzymes (or the related drug CM-AT), folic acid (or the related drug, leucovorin), L-carnitine, L-carnosine, melatonin, multivitamins and multiminerals, N-acetyl cysteine (NAC), omega-3 fatty acids (found in fish oil), probiotics, sulforaphane (from broccoli seed and sprout extract), ubiquinol (the active form of CoQ10), and vitamins B-12, C and D.

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