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Question:
What is Brain Bright and can it really improve memory or cognition?

Answer:
Brain Bright (BioTrust Nutrition) is promoted on the company's website as a "science-backed" "triple-action brain enhancement formula" which promises to provide: 1) greatly improved memory and recall, 2) immediate concentration and razor-sharp focus and 3) second-to-none long-term brain health (by shielding the brain from toxins). 

Evidence:
While the ingredients (and the amounts of these ingredients) in Brain Bright are each supported by some research suggesting a potential benefit, there are no published clinical studies on the effects of these ingredients when combined.

The claims made on the website appear to be based on an unpublished study, along with studies by others on the different ingredients listed in the product.

BioTrust provided ConsumerLab.com with a summary of the unpublished clinical trial -- which is cited on the company's website and referred to in this blog post by a BioTrust Nutrition "affiliate" (someone who is paid a commission for referring customers). The study involved 29 healthy adults between the ages of 19 and 68 (average age not given). It found that 2 tablets of Brain Bright taken daily for one week appeared to slightly reduce the number of mistakes on a test of concentration and short-term memory (approximately 1 mistake vs. 2.5 mistakes, respectively), but did not improve reaction time, processing speed or attention, compared to placebo. However, as data was not provided and the study results did not undergo peer-review for publication, it's difficult to draw any meaningful conclusions. In addition, no information about adverse effects was included.

Here is the evidence for each of the key ingredients in Brain Bright based on studies of the individual ingredients. You can use the links to get more information about each ingredient on ConsumerLab.com. Also shown is the amount of each ingredient listed in the suggested daily serving size of 2 tablets:

B Vitamins (riboflavin (8 mg), B-6 (20 mg), folate (as folic acid) (800 mcg), B-12 (methylcobalamin) (500 mcg) - The same doses of B-6, folic acid, and B-12, taken together, were found in one clinical study to slow cognitive decline in people age 70 years or older with mild cognitive impairment (riboflavin, however, was not used in the study).

Gingko biloba (240 mg of extract standardized to 24% glycosides, 6% lactones, and < 1 ppm ginkgolic acid) - Although this amount and type of extract is in-line with those used in some clinical studies for cognitive function, some experts have concluded there is little evidence that gingko improves cognitive function. The Brain Bright claim of "second-to-none long term brain health (by shielding the brain from toxins)" appears to be based on laboratory and animals studies demonstrating the antioxidant activity of ginkgo glycosides. However, we are not aware of any studies demonstrating long-term brain health benefits based on gingko's antioxidant properties.

Rhodiola rosea (200 mg root extract standardized to 5% rosavins and 2% salidrosides) — Doses in this range have shown some efficacy for improving certain measures memory and mental fatigue in a few small studies. However, overall, due to contradictory findings and design flaws in the studies, some researchers concluded there is insufficient evidence for this use.

N-acetyl-L-tyrosine (500 mg) - N-acetyl-L-tyrosine is converted into the amino acid tyrosine in the body. Although a few, small studies suggest tyrosine may improve memory or mental function in people who are sleep deprived or exposed to other forms of stress, it should be noted that these studies used higher doses of L-tyrosine (2,000 mg to 15,000 mg). In addition, it's not clear how much N-acetyl-L-tyrosine is actually converted into tyrosine in the body (Magnusson, Metabolism 1989; Van Goudoever, J Parenter Enteral Nutr 1994).

Acetyl-L-carnitine (500 mg) - There is some evidence that acetyl-L-carnitine may provide some help for age-related memory impairment, however, typically at a higher dosage (1,500 to 2,000 mg).

L-theanine (100 mg) - There is evidence that taking 50 mg of this amino acid (which is also found in black and green tea) may increase alpha brain wave activity, which plays an important role in attention, within less than an hour of taking. This research may be part of the basis for the claim that Brain Bright promise of "immediate concentration." 

Brain Bright also contains 5 mg of black pepper extract (BioPerine), an ingredient which is sometimes added to supplements to enhance the bioavailability of certain ingredients.

Safety:
It's important to note that the directions for use state: "Take 1 tablet 2 times daily, preferably without food, or, for enhanced concentration take 2 tablets as needed. Do not exceed 6 tablets per day." Taking the maximum recommended dosage of 6 tablets would provide three times the dosages of each ingredient as listed above. There are risks associated with taking such high doses of some of these ingredients, including vitamin B-6, B-12 and folic acid. Furthermore, there are no published studies on the safety of taking all of these ingredients together. For example, both Ginkgo biloba and Rhodiola may lower blood sugar, and both Rhodiola and L-theanine may lower blood pressure.

There are also potential interactions with medications for some of these ingredients. More information about potential side-effects and drug interactions for each ingredient can be found in the "Concerns and Cautions" sections of ConsumerLab.com's product reviews, which you can find by clicking on the above links to each review.

ConsumerLab.com has not tested Brain Bright to determine whether this product contains what it claims, and without contaminants. 

Cost: Brain Bright costs $49 for a bottle containing 60 tablets - a 30 day supply if you take the recommended 2 per day. The website claims there is a one-year money back guarantee and you will not be enrolled in an auto-delivery program. 

The bottom line:
Brain Bright contains several ingredients in doses which some small studies suggest may help to improve memory and cognition. However, there are no published clinical studies showing that these ingredients are safe or effective when taken together as in the Brain Bright formula. Furthermore, the overall evidence for two of its main ingredients, ginkgo and rhodiola, is currently considered insufficient for memory and cognition, and the evidence for the other ingredients is quite preliminary. 

See the Encyclopedia article about Enhancing Memory and Mental Function for more information.

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Comments
Add Comment

Louise8611   April 4, 2016
I am amazed once again by the thorough examination of Brain Bright by CL; putting all the ingredients together and examining the product as thoroughly as you did saved me DAYS of research from which I otherwise might, and probably would have, missed. I trust CL and will always. Once again you have saved me from myself in my efforts to seek even more benefits presented tantalizingly on the internet.

Thank you so much. I am truly grateful.

Sincerely,
Louise McCarthy

ConsumerLab.com   April 4, 2016
Thank you for your kind words Louise! We are glad this was helpful for you.

Jeannie Marie8599   April 3, 2016
Hi! As a PubMed junkie I know I stumbled upon a study that linked consumption of ginkgo biloba with glaucoma (pressure behind the eye?) For this reason I never take it or recommend it. Consumer Labs might want to look into this. I greatly appreciate the work of Consumer Labs. YES! Even those of us who devote great amounts of time doing research on Pub Med to make informed decisions on supplements, appreciate your valuable work. Thanks.

ConsumerLab.com   April 11, 2016
Hi Jeannie - We are aware of some studies (not all have found a benefit) showing that in people with normal tension glaucoma, ginkgo biloba extract increased blood flow to certain parts of the eye (http://www.ncbi.nlm.nih.gov/pubmed/21976939) and improved pre-existing visual field damage (without changes in eye pressure) (http://www.ncbi.nlm.nih.gov/pubmed/12578781), but we are not aware of a link between taking ginkgo and an increased risk of glaucoma. Can you please let us know which study you are referring to?

Jeannie Marie8630   April 11, 2016
Thank you pointing this out. Not much time here but after a quick review of the research on Gingko Biloba on Pub Med failed to show any research indicated that the consumption of this alternative herbal medication had any real negative consequences. In fact as you pointed out it has been shown to reduce the oxidatoxidative stress at the level of the mitochondria found in glaucoma.
Most likely I heard about this association of ginkgo biloba and increased IOP from the network news. FAR TOO much of their revenue comes from Big Pharma - and they love to stoke fear, real or imagined, about any "alternative" treatment or dietary supplement into the hearts and minds of the American consumer.
Thanks again!

ConsumerLab.com   April 11, 2016
Thank you for your kind words Jeannie.

We are aware of some studies (not all have found a benefit) showing that in people with normal tension glaucoma, ginkgo biloba extract increased blood flow to certain parts of the eye (http://www.ncbi.nlm.nih.gov/pubmed/21976939) and improved pre-existing visual field damage (without changes in eye pressure) (http://www.ncbi.nlm.nih.gov/pubmed/12578781), but we are not aware of a link between taking ginkgo and an increased risk of glaucoma. Can you please let us know which study you are referring to?

Lisa 11615   January 22, 2017
I have been taking Brain Bright for a almost a month and I feel like it has helped some with my ability to stay focused. I have no actual proof that taking Brain Bright is the reason but I feel like it has helped. I am going to take it for another couple of months and see how I do on it. I only take one a day..not two.

This is all based on my personal use and opinion.

Thanks for all the hard work that CL does to find out all this info to help us. It is greatly appreciated

This CL Answer initially posted on 4/2/2016. Last updated 8/2/2017.

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