Product Reviews
Milk Thistle Supplements Review

Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.
Initial Posting: 8/1/20 

Find the Best Milk Thistle Supplement

Tests and Reviews of Popular Milk Thistle Supplements & CL's Top Picks

Milk Thistle and Liver Formula Supplements Reviewed by
Alphabetical list of milk thistle supplement brands compared in this review
California Gold Nutrition EuroHerbs Milk Thistle Nature's Sunshine Milk Thistle Swanson Milk Thistle
CVS Health Milk Thistle 250 NOW Silymarin Trunature Premium Milk Thistle
Jarrow Formulas Milk Thistle 150 mg Pure Encapsulations Silymarin Vitamin Shoppe Milk Thistle Extract
California Gold Nutrition EuroHerbs Milk Thistle CVS Health Milk Thistle 250 Jarrow Formulas Milk Thistle 150 mg Nature's Sunshine Milk Thistle NOW Silymarin Pure Encapsulations Silymarin Swanson Milk Thistle Trunature Premium Milk Thistle Vitamin Shoppe Milk Thistle Extract
Make sure the milk thistle supplement you take passed our test and is right for you!
Isn't your health worth it?

If you already are a member, SIGN IN now.
Summary: What You Need to Know About Milk Thistle Supplements
  • What does milk thistle do? For people with type 2 diabetes, milk thistle may decrease blood sugar, hemoglobin A1c, and LDL cholesterol levels when used with conventional therapy. The evidence is mixed as to whether it improves liver function in people with chronic active hepatitis (see What It Does).
  • What is silymarin? Silymarin is the term for a specific group of chemically-related compounds found in milk thistle. Silymarin is thought to be responsible for some of the herb's effects and is used as a marker of milk thistle strength (see What It Is).
  • What to look for with milk thistle? Milk thistle comes in various forms and concentrations, but most clinical studies of milk thistle's effectiveness have used extracts at a dose of about 200 mg of extract taken 2 to 3 times per day. The amount of silymarin in these extracts is about 58% of its weight (although this has been reported as 80% when using a non-specific, older method of testing known as UV-VIS) (see What to Consider When Buying and Using for dosage and other details).
  • What did CL find in its tests of milk thistle supplements? The amount of silymarin per serving ranged from 61.2 mg to 202 mg. For most products, these amounts were far less than a consumer might expect from labels, leading CL to rate several products as having poor labeling (see What CL Found).
  • Which is the best milk thistle supplement? Among products Approved for Quality by one was chosen as CL's Top Pick for providing a substantial amount of silymarin, appropriate usage instructions, and superior value.
  • What are the side effects of milk thistle? Milk thistle is generally well tolerated but, infrequently, can have a laxative or other gastrointestinal side-effect. Allergic reactions can occur, especially in people who are sensitive to related plants and it may interact with certain medications (see Concerns and Cautions).
You must be a member to get the full test results along with recommendations and quality ratings. You will get results for nine milk thistle supplements selected by, including capsules, tablets and powders.

In this comprehensive review, you'll discover:
    • Which milk thistle supplements failed our tests and which ones passed
    • CL's Top Pick among milk thistle supplements for providing a substantial amount of silymarin, appropriate usage instructions, and superior value
    • The evidence behind other ingredients in liver formulas such as artichoke extract, schizandra (schisandra) extract, and phyllanthus extract. 
    • How "silymarin," "silybin," and "flavonoids" differ as listed ingredients in milk thistle 
    • The clinical evidence for and against milk thistle for lowering blood sugar and cholesterol levels, improving liver function, and other uses of milk thistle 
    • Concerns, cautions, side effects, and drug interactions with milk thistle 

If you already are a member, SIGN IN now.

Learn More About Milk Thistle Supplements Answers -- for Milk Thistle Supplements Review
Are supplements which claim increased absorption or improved bioavailability telling the truth? Is it worth paying more for these? Are there concerns? Get the answer >>

Can drinking coffee can prevent gallstones? Can supplements help? Get the answer >>

Which supplements can help lower or control my blood sugar? Get the answer >>

Is it true that milk thistle supplements can be contaminated with toxins that can be harmful to the liver? Get the answer >>

Do any supplements help prevent or reduce eye floaters? Get the answer >>
Join |  Sign In
Join Us on Facebook! Join Us on Instagram! Join Us on Twitter! Join Us on YouTube! Join Us on YouTube!
Product Reviews
Brands Tested
Health Conditions
CL Answers
Clinical Updates
Recalls & Warnings
Recommended Intakes
Where to Buy Products
Testing Program
How Products Were Tested
Quality Certification Program
Join CL Today
Join Free Newsletter
Group Subscriptions
Gift Membership
About Us
The CL Seal
CL Survey
Privacy Policy
Contact Us/Help

©2020, LLC. All rights reserved. A single copy of a report may be printed for personal use by the subscriber. It is otherwise unlawful to print, download, store or distribute content from this site without permission. name and flask logo are both registered trademarks of, LLC. This site is intended for informational purposes only and not to provide medical advice.