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Nattokinase Supplements Review

Choose the Best Nattokinase Supplement. CL Tests Reveal Which Nattokinase Suppplements Provide the Best Quality & Value.

Latest Update

Nattokinase

Medically reviewed and edited by Tod Cooperman, M.D.

Updated July 21, 2025 ⓘ

Nattokinase Supplements Tested by Consumerlab.com

Products tested in 2016

+— 29 sources

In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:

Summary

Health benefits of nattokinase supplements:
Nattokinase supplements have been promoted to reduce the risk of blood clots and reduce blood pressure. However, the evidence for these effects in people remains preliminary: No study has definitively shown a reduction in clots in people from using nattokinase, although a reduction in blood clotting factors has been demonstrated, and nattokinase causes only a small reduction blood pressure. (See "What It Does")
How to choose a nattokinase supplement:
When choosing a nattokinase supplement, it is important to look for one which lists its enzyme activity, which will be in FU (fibrin degradation or fibrinolytic units). Listing just the amount of enzyme in milligrams doesn't tell you enough, since not all nattokinase is equally active. You'll want a product providing at least 1,000 FU per pill or unit (see "What It Is"). Also, check that ConsumerLab.com or another reputable independent 3rd party has verified the enzyme activity, as not all products provide the activity they list (see "What CL Found" and How Products Were Evaluated).
Best value for nattokinase:
Products which ConsumerLab.com found to contain their listed nattokinase enzyme activity are indicated as Approved in the 3rd column of the Results Table below. Among those, several provide the best value (i.e., greatest enzyme activity at lowest cost) -- see Top Picks.
Nattokinase safety and side effects:
Short term use of nattokinase supplements is generally well-tolerated but people who are taking medications such as blood-thinners or blood-pressure lowering medication should use them only with caution (See "Concerns and Cautions"). Nattokinase may also increase bleeding in the event of trauma or during and after surgery. Many nattokinase supplements contain soy and should not be used by people with an allergy to soy. See the last column of the Results Table to find out which claim soy.

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Nattokinase supplements compared in this review

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Arthur Andrew Medical Nattovéna

Dr. David Williams Nattokinase

Enzymedica Natto-K

Healthy Origins Nattokinase

KAL Nattokinase 100 mg

Natural Factors Nattokinase 100 mg

NOW Nattokinase

Ortho Molecular Products Nattokinase

Puritan's Pride Nattokinase

Solgar Nattokinase Complex

The Vitamin Shoppe Nattokinase with Rutin

Vitamin World Nattokinase

You must be a member to get the full test results for nattokinase supplements along with ConsumerLab.com recommendations and quality ratings. In this comprehensive review of nattokinase supplements, you'll get test results and quality ratings for 11 supplements (including two which passed our voluntary Quality Certification Program), as well as information about a supplement similar to one which was tested. You'll discover:

Which nattokinase supplements passed or failed ConsumerLab.com's testing and review
Which nattokinase supplements are the best value and our Top Picks

The evidence regarding the use of nattokinase for reduction in blood clots, blood pressure reduction, cholesterol and triglyceride lowering, and reduced progression of atherosclerosis
The dosage of nattokinase for different applications and the related clinical evidence
Potential side effects, allergic reactions, and drug interactions with nattokinase

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Nattokinase Supplements Review

Choose the Best Nattokinase Supplement. CL Tests Reveal Which Nattokinase Suppplements Provide the Best Quality & Value.

Summary

Health benefits of nattokinase supplements:

How to choose a nattokinase supplement:

Best value for nattokinase:

Nattokinase safety and side effects:

Make sure you're choosing the best nattokinase supplements approved in our tests!