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Last Updated: 10/18/2021 |

Pyrroloquinoline quinone (PQQ) supplements compared in this review


Doctor's Best PQQ With BioPQQ


Double Wood Supplements PQQ


HTN PQQ 40 mg


Jarrow Formulas PQQ 20 mg


Kal PQQ 5 mg


Life Extension CoQ10 100 mg with PQQ


Swanson PQQ


Vitacost PQQ 10 mg

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  • What is PQQ?

    Pyrroloquinoline quinone (PQQ) is a reddish-brown antioxidant compound that plays a role in releasing energy in cells, although it is not a required nutrient. It is found in very small amounts in foods. Supplements, which are typically produced synthetically or by bacterial fermentation as PQQ disodium salt, provide much larger amounts (5 to 20 mg per serving). PQQ has been sold in the U.S. since 2008. (See What It Is)
  • What are the health benefits of PQQ?

    Animal studies have suggested a range of possible benefits for PQQ, but clinical studies in people have generally been extremely limited and have not shown much benefit. Studies have focused on uses for memory and cognition, energy and mood, inflammation, athletic-endurance and body composition, cholesterol-lowering, and reducing statin-related side effects. (See What It Does)
  • How do PQQ supplements compare?

    All of the PQQ supplements purchased and tested by ConsumerLab provided PQQ as the disodium salt, claiming 5 to 40 mg per serving. Some provided branded forms of PQQ, such as BioPQQ and PureQQ.
  • What did ConsumerLab find in testing PQQ supplements?

    Only five of the seven PQQ supplements selected by ConsumerLab for testing provided their listed amounts of PQQ. Two products provided less PQQ than claimed. None of the supplements were found to be contaminated with lead, cadmium, or arsenic. (See What CL Found)
  • What is the best PQQ supplement?

    Among the products that passed testing and were Approved for quality, ConsumerLab selected one as its overall Top Pick because it provided the most commonly used dose of PQQ (20 mg) and was favorably priced. A second Approved PQQ supplement was a Top Pick for lower dosage (10 mg). (See Top Picks)
  • Is PQQ safe?

    PQQ has not undergone safety testing in people, although animal studies have not indicated a safety problem. The FDA has not objected to notifications it has received from companies selling PQQ that have self-certified that their ingredients should be generally recognized as safe (GRAS). (See Concerns and Cautions)
You must be a member to get the full test results along with recommendations and quality ratings. You will get results for seven PQQ supplements selected by and one other supplement that passed testing in its voluntary Quality Certification Program. In this comprehensive review, you'll discover:

  • Which PQQ supplements passed or failed our tests
  •'s Top Picks, representing the best quality PQQ supplements at the best price
  • The evidence for and against the promoted health benefits of PQQ, including its anti-oxidant effects, memory and cognition, energy and mood, inflammation, athletic-endurance and body composition, cholesterol-lowering, and reducing statin-related side effects.
  • Information about branded forms of PQQ, such as BioPQQ and PureQQ
  • How to buy and use PQQ supplements
  • The safety of PQQ supplements

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