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Digestive Enzymes

Trying to find the best digestive enzyme supplement? We found major differences in their strengths. See our tests, comparisons, and Top Picks. Also learn about pancreatin, proteases including bromelain and papain, lipase, amylase and more. Get the evidence for use for digestive symptoms and other conditions, as well side-effects and cautions.

Digestive Enzymes Review

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CL Answer

Do any supplements help with pancreatitis? Do any cause pancreatitis?

Find out if supplements including digestive enzymes, antioxidants, or medium-chain triglycerides are beneficial for chronic pancreatitis, and learn which supplements might worsen symptoms.

Person with pancreatitis holding their abdomen

CL Answer

Can heat and humidity destroy whey protein and other sports nutrition supplements (e.g., creatine, BCAAs, digestive enzymes) during shipping or while storing at home?

Find out if heat and humidity can degrade creatine, BCAAs, digestive enzymes, and other muscle enhancing supplements.

How Heat Effects Whey Protein and Creatine -- Scoop of Protein Powder

CL Answer

Since the COVID-19 drug, Paxlovid, works by blocking a protease enzyme, should I be concerned about taking digestive enzymes that contain proteases?

Find out if taking digestive enzyme supplements that contain proteases might interact with medications that work by blocking a protease enzyme, including the COVID-19 drug Paxlovid.

Digestive enzyme supplements placed on a table between a fork and knife

CL Answer

Which supplements or OTC medications help reduce flatulence (gas), and are there any that make it worse?

Find out which supplements may help reduce flatulence (gas), and learn which supplements or foods may worsen symptoms of flatulence.

Older woman sitting on her bed and holding her stomach due to gas and bloating

CL Answer

Which supplements, foods or diet and lifestyle changes help relieve acid reflux (heartburn), and which worsen it?

Find out which supplements and foods can help relieve acid reflux, and which can make it worse.

Supplements Making Acid Reflux Worse -- Man with acid reflux pain

Product Review

Fruits, Veggies, and Other Greens Supplements Review (Including Spirulina and Chlorella)

Avoid Lead in Greens, Problems with Pills, and Don't Give Up Eating Whole Foods.

Greens Review Oct 2023

Clinical Update

6/03/2022

Digestive Enzymes for IBS?

Does taking digestive enzymes reduce symptoms of irritable bowel syndrome (IBS)? Find out in our updated Digestive Enzyme Supplements Review.

Clinical Update

11/28/2023

Enzymes for Eye Floaters

Does supplementing with digestive enzymes reduce eye floaters and improve sight? See what a recent study showed in the Eye Floaters section of our Digestive Enzymes Supplements Review.

Also see: Do any supplements help prevent or reduce eye floaters?

News Release

February 24, 2022

Consumers Returned to Pre-Pandemic Supplement Usage in 2021, ConsumerLab Survey Reveals

White Plains, New York, February 24, 2022 —A survey of 8,049 people who use dietary supplements shows many supplements that declined in use in 2020 began bouncing back in 2021, such as magnesium (+2.4 percentage points), and CoQ10 (+2.7 pts).

News Release

February 26, 2021

COVID Changed Supplement Popularity in 2020, ConsumerLab Survey Reveals

White Plains, New York, February 26, 2021 — A survey of 9,647 people who use dietary supplements shows that the supplements which experienced the greatest growth in popularity in 2020 were those being promoted to prevent or treat infection with SARS-CoV-2, the coronavirus that causes COVID-19.

CL Answer

What is Skinny Fiber and does it really work? I see that glucomannan is a key ingredient. What is that?

Learn more about Skinny Fiber, including its key ingredient glucomannan, evidence from clinical studies, dosage info, and safety.

Skinny Fiber

CL Answer

I take omeprazole (Prilosec), a proton pump inhibitor, to reduce stomach acid. Are there supplements I should avoid, or be taking, due to this drug?

Supplement interactions with proton pump inhibitor (PPI) drugs like omeprazole (Prilosec) and Nexium.

CL Answer

I take warfarin (Coumadin), an anticoagulant drug. Are there supplements I should avoid, or be taking, due to this drug?

Find out which supplements should be avoided when taking blood thinners (anticoagulants) like warfarin (Coumadin), including vitamin K, St. John's wort, and curcumin.

Warfarin Supplement Interactions -- bottle of pink warfarin tablets

CL Answer

Which supplements are helpful to have when traveling? Any tips on how to best store supplements on trips?

Find out which vitamins & supplements can be helpful when traveling, including melatonin, ginger, and more, and find out how you can carry them with you.

Product Review

Protein Powders, Shakes, and Meal Replacements Review

Find Out Which Protein Products Passed or Failed Our Tests

CL Answer

What are the health benefits of tart cherry juice?

See the evidence for tart cherry juice health benefits from clinical studies. Find out if tart cherry has anti-inflammatory effects, if it can improve sleep, lower high blood pressure, or help for muscle pain and osteoarthritis.

Tart Cherry Benefits -- glass of cherry juice and two tart cherries

CL Answer

Which supplements and foods can help lower or control blood sugar?

Find out which supplements can help lower or control blood sugar. Supplements including turmeric/curcumin, fiber, cinnamon, and ginseng are believed to help lower blood sugar.

Blood Sugar Control -- blood test and blood sugar chart

Clinical Update

12/15/2018

Enzymes for Indigestion

Will taking digestive enzymes reduce indigestion? Although not all studies have shown a benefit, a recent study suggested improvements with no adverse effects. For details, see the Digestive Discomfort section of the Digestive Enzyme Supplements Review. (Also see our top choices for enzyme supplements).

Clinical Update

12/06/2022

Digestive Enzymes – Prescription vs. Supplements

A CL member with chronic pancreatitis asked about alternatives to costly prescription enzymes. See our Digestive Enzyme Supplements Review for information about prescription enzymes as well as supplements similar to prescription products.

News Release

May 15, 2019

ConsumerLab Tests Reveal Big Differences in Digestive Enzyme Supplements

White Plains, New York, May 15, 2019 — Digestive enzyme supplements can help improve digestion and the absorption of nutrients, and may reduce symptoms of indigestion. But to work, they must provide a certain amount of enzyme activity.

CL Answer

What are the health benefits of green tea, and is it safe?

ConsumerLab explains green tea's potential health benefits for everything from fighting cancer to helping your heart.

Cup of green tea with dried tea leaves

Product Review

Green Tea Review: Tea Bags, Matcha Powders, and Supplements

Some green teas provide barely any green tea polyphenols, while some others are high strength. See the Test Results and Our Top Picks for Green Tea.

Green Tea Review 2024

CL Answer

Are there supplements I should avoid when taking apixaban (Eliquis) or similar blood thinner drugs like Xarelto?

Learn about supplement interactions with apixaban (Eliquis), rivaroxaban (Xarelto) and other blood thinner drugs in the direct factor Xa inhibitors class.

Eliquis Supplement Interactions -- box of Eliquis

CL Answer

I recently read that turmeric is only effective if it is combined with black pepper. Is this true?

Find out the best way to take turmeric and curcumin supplements to increase absorption and bioavailability. ConsumerLab.com's answer explains.

Is Turmeric Only Effective with Black Pepper? -- Turmeric Supplement and Black Pepper

CL Answer

Are enteric coated supplements better than non-enteric coated ones?

Learn about the pros and cons of enterically coated supplements, including ingredient absorption,safety and price.

Glass of Water and White Pill

Product Review

Lactose Intolerance Products Review (Lactase Enzyme Supplements and Lactose-Free Milks)

Choose the Best Lactase Enzyme Supplement and Lactose-Free Milk. Find a CL Approved Lactose Intolerance Product.

Lactase Supplements Reviewed by ConsumerLab.com

CL Answer

What are the health benefits of serrapeptase?

Serrapeptase is a proteolytic enzyme. Learn more about its health effects, including whether evidence supports its use for pain, inflammation, and heart health.

Serrapeptase for Inflammation and Pain

CL Answer

How can I find out where a vitamin or supplement is made and where its ingredients come from, such as China or the USA?

Learn more about the manufacturing, distribution, and ingredients of a supplement, including FDA regulations.

How to Find Out Where A Supplement Is Made -- Supplement Label

Product Review

Nattokinase Supplements Review

Choose the Best Nattokinase Supplement. CL Tests Reveal Which Nattokinase Suppplements Provide the Best Quality & Value.

Nattokinase Supplements Tested by Consumerlab.com

CL Answer

Which supplements are important after bariatric surgery (i.e., weight loss or stomach-reducing surgery)? Are there any I should avoid?

Find out which supplements may help after weight loss or stomach reducing surgery, including iron and calcium, and which should be avoided.

Bypass Surgery Sign

CL Answer

Do any supplements help prevent or reduce eye floaters?

Find out eye floaters (vitreous floaters) be treated with supplements like vitamin C, lutein, ginkgo, milk thistle, collagen or hyaluronic acid, or with products such as VitreousHealth.

How to Reduce Eye Floaters With Vitamins & Supplements -- Close-up of an eye

CL Answer

Do any supplements help for irritable bowel syndrome (IBS)?

IBS supplements may help reduce irritable bowel symptoms such as pain, diarrhea and constipation. Supplements include probiotics, melatonin, and flaxseed.

Supplements for IBS? -- Women With Stomach Pain

CL Answer

Do any supplements naturally suppress appetite and help with weight loss?

Learn which natural ingredients can suppress appetite and find if these natural appetite suppressants help with weight loss.

Container of natural appetite suppressant supplement with measuring tape and scale in background

CL Answer

Which supplements help with arthritis?

Learn more about supplements for joint health, including products such as Wobenzym and Zyflamend and ingredients such as collagen, curcumin, glucosamine and chondroitin, hyaluronic acid, magnesium, omega-3 fatty acids, palmitoylethanolamide (PEA), SAMe, and others.

Supplements for Osteoarthritis and Rheumatoid Arthritis -- Women With Arthritic Hands

CL Answer

Supplements for Age-Related Muscle Loss

Find out if protein supplements, fish oil, vitamin D, and other supplements can help older adults build and maintain muscle, and help prevent age-related muscle loss (sarcopenia).

CL Answer

I read that famotidine (Pepcid) may help treat COVID-19. Is this true? Might a proton pump inhibitor, like Prilosec, help?

Pepcid (famotidine) was reported to improve outcomes in people with COVID-19 in China. But is there evidence that Pepcid really helps to treat COVID-19?

Can Pepcic (famotidine) Treat COVID-19? -- Box of Pepcid and Handout About COVID-19

CL Answer

Is bromelain a good alternative to NSAIDs, like ibuprofen, for muscle or joint pain?

Do bromelain supplements have benefits? Learn more about its safety, and if it is a good alternative to NSAIDs like ibuprofen.

Bromelain Supplements Top View

CL Answer

Where to Safely Buy Real Vitamins and Supplements Online, Not Fakes or Counterfeits

ConsumerLab explains how to avoid counterfeit vitamins and supplements when shopping online on Amazon, Walmart.com, and other sites. Learn to identify authorized sites and sellers and avoid fake supplements. Use the brand-by-brand guide to protect yourself from risk.

Woman in Orange Sweater

Clinical Update

9/21/2021

Enzyme Supplements for Eye Floaters?

Can enzyme supplements (bromelain, papain and ficin) reduce eye floaters? Find out what a recent study suggests in the What They Do section of our Digestive Enzyme Supplements Review.

Also see our answer to the question: Do any supplements help prevent or reduce eye floaters?

News Release

February 24, 2017

Vitamin D Supplements Maintain Top Spot in Popularity, as Probiotics Surpass Multivitamins to #4 Behind Fish Oil and CoQ10 in Latest ConsumerLab.com Survey

White Plains, New York, February 24, 2017 — A recent survey of over 9,505 people who use dietary supplements shows the most popular dietary supplement to be vitamin D, followed by fish oil, CoQ10, probiotics, and multivitamins.

News Release

May 05, 2015

ConsumerLab.com's Tests of Digestive Enzyme Supplements Reveal What Labels Don't

White Plains, New York, May 5, 2015 — How do you know if your digestive enzyme supplement is truly active? The only way to know for sure is to test it on fats, carbohydrates, proteins and other parts of food which it is expected to digest. That's exactly what ConsumerLab.

News Release

February 25, 2015

Top-rated Vitamin and Supplement Brands and Merchants for 2015 Based on Consumer Satisfaction -- Results of the ConsumerLab.com Survey of Vitamin & Supplement Users

Each year, ConsumerLab.com surveys its free e-newsletter subscribers about the vitamins and supplements that they use. The results below are based on 10,329 responses collected in November, 2014. Respondents gave ratings for 1,709 brands and 891 merchants.

Recalls & Warnings

January 20, 2021

Seller of Omega-3 Warned for Making Claims to Treat Focus, Mood

On December 9, 2020, the FDA issued a warning letter to Bodyhealth.com, LLC following a review of the company's website, which found statements made about the company's products Healthy-Thin Energize, Body Detox (Oral Spray), and Omega 3 Health to be drug claims.

Recalls & Warnings

January 12, 2021

Seller of Cholesterol, Weight Loss Products, and More Warned for Claims

On November 17, 2020, the FDA issued a warning letter to Bonagens following a review of the company's website, which found statements made about the company's products Anti-Aging Supports, Cholesterol & Diabetes Control, Gout Control, Hypertension Control, Liver Supports, Lungs ...

Recalls & Warnings

January 12, 2021

FDA Warns Seller of Joint and Hair Loss Products

On December 22, 2020, the FDA issued a warning letter to Speedwinds Nutrition, Inc. following a review of the company's website, which found statements made about the company's products Synotrex and Sephren to be drug claims.

Recalls & Warnings

January 12, 2021

FDA Warns Seller of Turmeric, Ashwagandha, Glucosamine, and More

On December 18, 2020, the FDA issued a warning letter to Reddy Naturals following a review of the company's website, which found statements made about the company's products Glycostasis, Glucosamine Curcumin, Turmeric 50, Turmeric Curcumin, Cetyl Curcumin, Ashwagandha, Huruli, ...

Recalls & Warnings

December 15, 2020

FDA Warns Seller of Evening Primrose Oil and Beta Glucan

On December 2, 2020, the FDA issued a warning letter to Smoky Mountain Naturals, LLC following a review of the company's website, which found statements made about the company's products Evening Primrose Oil and Beta Glucan to be drug claims.

Recalls & Warnings

November 10, 2020

FDA Warns Seller of Digestive Enzymes, Nattokinase, and More

On October 27, 2020, the FDA issued a warning letter to World Nutrition, Inc.

News Release

February 12, 2014

Top-rated Vitamin and Supplement Brands and Merchants for 2014 Based on Consumer Satisfaction -- Results of the ConsumerLab.com Survey of Vitamin & Supplement Users

Each year, ConsumerLab.com surveys its free e-newsletter subscribers about the vitamins and supplements that they use. The results below are based on 10,326 responses collected in November, 2013. Respondents gave ratings for 1,639 brands and 788 merchants.

Clinical Update

3/24/2023

Bromelain Supplements on Amazon Fail Tests

Only four of 20 brands of bromelain purchased on Amazon provided the enzyme activity expected from their labels, three of which had no detectable enzyme activity, according to a recent report. For details by brand, see the Quality Concerns section of our Digestive Enzyme Supplements Review, which includes our Top Picks among digestive enzyme products.

News Release

November 25, 2013

Many Probiotic Supplements Fall Short on Listed Amounts of Helpful Organisms

White Plains, New York, November 25, 2013 — Probiotic supplements and foods containing "friendly" bacteria or yeast have become popular among people hoping to improve bowel function, immunity, and even mood.

Recalls & Warnings

January 18, 2002

Recall of Pepsin-containing Digestive Supplements

The U.S. Food and Drug Administration (FDA) released the following Class I recall information in its January 16, 2002 Enforcement Report.

News Release

January 31, 2013

Use of CoQ10, Digestive Enzymes, Probiotics and B Vitamins on the Rise According to ConsumerLab.com Survey

White Plains, New York — February 1, 2013 — A recent survey of over 10,000 people who take supplements shows that CoQ10, digestive enzymes, probiotics, and B vitamins are the four categories experiencing the most growth over the prior year.

Clinical Update

1/14/2017

Enzymes for Muscle Soreness

A blend of enzymes reduced delayed-onset muscle soreness after exercise in healthy men. For details, see the "What They Do" section of the Digestive Enzyme Supplements Review >>

News Release

October 31, 2011

Supplements for lactose intolerance vary in strength and cost, and some offer no benefit, according to ConsumerLab.com

White Plains, New York — October 31, 2011 — Can lactose-free milks and lactase enzyme supplements provide help to the millions of Americans with lactose intolerance.

Recalls & Warnings

April 23, 2013

Seller of Digestion, Thyroid and Vitamin D Supplements Warned For Drug Claims

On November 5, 2012, the FDA issued a warning letter to The Women's Health Institute at Texas following a review of the company's various websites which found statements made about Digest + SEB, Iodine Plus 2, and D5000 Vitamin D dietary supplements to be drug claims.

Recalls & Warnings

October 12, 2013

Metagenics Enzyme Supplement Recalled Due To Drug Risk

On October 11, 2013, Metagenics Canada issued a voluntary recall of digestive enzyme supplement Spectrazyme, due to potential contamination with the prescription antibiotic chloramphenicol.

Recalls & Warnings

January 24, 2013

Food for Health Warned for Manufacturing Violations and Drug Claims on Supplements

On October 5, 2012, the FDA issued a warning letter to Food for Health International, LLC following a facility inspection which found the company's products, including Activz brand Vitamin D, Potassium Iodine, Organic Vitamin C, Whole 9 (a fruit and vegetable meal replacement shake) Control and VMA ...

Recalls & Warnings

October 11, 2013

Prebiotic and Digestive Enzyme Supplement Recalled Due To Drug Risk

On October 10, 2013, Adeeva Nutritionals Inc. issued a voluntary recall of digestive supplement Flora Essentials due to potential contamination with the prescription antibiotic chloramphenicol.

Recalls & Warnings

February 18, 2020

Seller of CoQ10, Resveratrol and More Warned for Manufacturing Violations

On February 5, 2020, the FDA issued a warning letter to R-Garden LLC, which found the company's Vitamin O, Gamma-Zyme, L.

Recalls & Warnings

September 25, 2018

FDA Warns Seller of Digestive Enzyme Supplements

On March 6, 2018, the FDA issued a warning letter to Uckele Health & Nutrition, Inc.

Recalls & Warnings

February 28, 2017

Multivitamin Recalled Due to Allergen Risk

On February 14, 2017, Licata Enterprises issued a recall of all lots of its Supreme One and Theravits 100 multiple vitamins because they contain fish liver oil but is labeled as containing "no common allergens.

Recalls & Warnings

November 21, 2012

Maker of Blood Pressure, Probiotic, Resveratrol and Hormonal Supplements Warned For Manufacturing Violations and Drug Claims

On November 2, 2012, the FDA issued a warning letter to Atrium, Inc. following a facility inspection which found a number of the company's dietary supplements to be adulterated or promoted as drugs.

Recalls & Warnings

September 10, 2012

Maker of Concussion Recovery Supplement Warned For Making Drug Claims

On August 28, 2012, the FDA issued a warning letter to Trinity Sports Group, Inc. after a review of the company's websites found statements about Neuro Impact Concussion Response Formula constituted drug claims not permitted on supplements. 

Recalls & Warnings

September 05, 2014

Seller of "Nerve", "Cleanse" and Probiotic Supplements Warned for Drug Claims

On July 30, 2014, the FDA issued a warning letter to Plexus Worldwide, Inc., following a review of the company's website and product labels, which found statements made about Fast Relief, BioCleanse and ProBio5 to be drug claims.

Recalls & Warnings

February 01, 2013

Lactase Enzyme Supplement Recalled

On November 13, 2012, Cardinal Health issued a voluntary recall of specific lots of Dairy Aid Lactase Enzyme Supplement 3,000 FCC Unit caplets because they are incorrectly labeled as 9,000 FCC Unit caplets.

Recalls & Warnings

November 01, 2013

Protein Shakes Containing Prescription Drug Pose Serious Health Risk

On November 1, 2013, Health Canada warned consumers that Vega One Vanilla Chai (sizes 437g and 874g) and Vega Sport Performance Chocolate nutritional shakes, by Sequel Naturals Ltd., have been found to contain the prescription antibiotic chloramphenicol.