Does AKG Extend Lifespan and Slow Aging?

Written by Tod Cooperman, M.D.

Published June 04, 2026

Bottles of commercially available AKG products

Answer:

AKG (alpha-ketoglutarate) is promoted as a "longevity" supplement. It is typically bound to calcium to stabilize it and called CaAKG (or dAKG — for delayed-release AKG). Both forms are sold as supplements, with CaAKG typically costing several times as much as AKG. CaAKG is sold by many supplement brands, such as Prohealth Longevity and Renue by Science, and it is sold in combination with vitamins in products such as Rejuvant.

Most of the interest in AKG has been driven by animal studies suggesting that it might slow the biological clock in cells and reduce aspects of inflammation, as well as very preliminary analyses of data from people using Rejuvant. Good clinical evidence showing that AKG or CaAKG prolong human lifespan or healthspan (i.e., time spent in good health) is lacking.

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