Initial Posting: 7/15/2017    Last Update: 7/15/2017
Answer: Although CoQ10 supplements are sometimes promoted for reducing wrinkles or "rejuvenating" aging skin, only one, small study found that a branded CoQ10 supplement reduced wrinkles around the eyes, nose and lips in middle-aged women.
There do not appear to be any studies showing that CoQ10, or any other supplement, can tighten loose skin, but there is some evidence that several other supplements may help to reduce wrinkles and/or increase skin elasticity.
Cocoa flavanols were found in one study to reduce the depth of "crow's feet" wrinkles around the eyes, and increase skin elasticity in older women with moderate sun damage and visible wrinkles.
There is some evidence that collagen supplements may be helpful, but be aware that the best evidence for this has been demonstrated in clinical studies using a specific, branded collagen ingredient. Bone broth and bone broth supplements can also be a good source of collagen, but there are no clinical studies on their use for reducing wrinkles or increasing skin elasticity.
There is preliminary evidence that astaxanthin supplements may reduce the area of wrinkled skin around the eyes — but not the depth of wrinkles.
Phytoceramides supplements, derived from plants such as wheat and rice, are promoted to hydrate and "plump" the skin for a more youthful appearance, but there is little evidence to support their use for reducing wrinkles, increasing elasticity, or improving the appearance of aging skin.