Initial Posting: 8/27/2016    Last Update: 6/20/2019
Answer: The MTHFR gene mutation may make your body less efficient at converting folic acid and folate into L-methylfolate, the active form of folate in the body. People with this mutation may also be more likely to be deficient in vitamin B-12. Although certain forms of B vitamins are sometimes promoted for people with this mutation, they may not be necessary. For more about this, see the What to Consider When Using section of the B Vitamin Supplements Review.