Studies have shown that high consumption of broccoli and other cabbage-family vegetables is associated with reduced risk of a variety of cancers. This has spurred research into potential anticancer effects of compounds that occur in these vegetables, such as indole-3-carbinol (I3C) and its derivative diindolylmethane (DIM), both of which are sold as supplements.
Preliminary research showed that I3C may benefit women with certain estrogen-sensitive cancers and precancers, such as ovarian cancer and cervical dysplasia, but there is concern that it may also have the potential to increase cancer risk in some situations. DIM, a chemical formed in the body upon ingestion of I3C, has also been studied for people with cancer (breast or prostate cancer) or pre-cancerous conditions (cervical dysplasia), but most clinical studies have shown limited to no benefit.
Sign in for more details, including information about the safety and possible side effects of these supplement ingredients.