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Our Members Asked:
What is hesperidin, what is it used for and is it safe?
Answer:
Hesperidin is a bioflavonoid found in oranges, lemons and other citrus fruits. It has shown anti-inflammatory, analgesic, antioxidant, anticancer, antiviral, and blood pressure lowering effects in laboratory studies (Garg, Phytother Res 2001). Based on these and other biological effects, hesperidin has been evaluated for numerous conditions, including heart health, problems with circulation, stroke, cognitive function, depression, cancer and other conditions, but evidence of benefit is limited and often mixed.
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Related CL Answers (8)
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Truth Science
June 22, 2025Bone Health: FDA-approved bone growth factor proteins (BMP2 and 7) are used in certain bone graft surgeries (spinal fusion, dental) but one side effect is bone overgrowth. Interestingly, dietary Hesperidin has been shown to temper this problem in animal studies.
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Michael16046
November 03, 2023What is the difference between Hesperidin and Hesperetin?
ConsumerLab.com
November 08, 2023Hesperetin is the non-sugar portion of hesperidin. Hesperidin is made up of hesperetin and rutinose (a sugar).
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Joel16043
May 07, 2023Hesperidin Is considered by some in Britain as a treatment to reduce eye floaters. What is your view?
ConsumerLab.com
September 20, 2023Preliminary evidence suggests that supplements containing hesperidin along with other ingredients may reduce visual discomfort due to eye floaters (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525826/; https://www.researchgate.net/publication/326345092_THE_EFFECT_OF_ORAL_SUPPLEMENTATION_WITH_L-LYSIN_HESPERIDIN_PROANTHOCYANIDINS_VITAMIN_C_AND_ZINC_ON_SUBJECTS_ASSESSEMENT_OF_THE_QUALITY_OF_VISION_IN_PATIENTS_WITH_VITREOUS_FLOATERS), but we are not aware of any high-quality clinical studies evaluating hesperidin alone for eye floaters.
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