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Information on SAMe (S-adenosyl-L-methionine)

Question:
I've read about several different forms of SAMe. Is one form better than another?
Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.

Answer:
SAMe is promoted to help with depression and joint pain. It is sold in different forms, depending on the compound used to stabilize it and help prevent degradation. Details about the various forms (tosylate, disulfate tosylate, disulfate ditosylate, and 1,4-butanedisulfonate), including evidence and what to look for on the label, are discussed in the SAMe Supplements Review >>

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This CL Answer initially posted on 11/4/2014. Last updated 12/12/2019.
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