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Phosphatidylserine Review 2024


  • What is phosphatidylserine?

    Phosphatidylserine (or phosphatidyl serine or just PS) is a component of cell membranes that plays a role in cell signaling in the brain. It is not an essential nutrient, as it is naturally produced in the body, and it can be obtained from animal organs and from lecithin from soybeans, sunflower seeds, and other plant sources. Early clinical studies were mainly conducted with phosphatidylserine from cow brain, but due to concerns about disease transmission, phosphatidylserine in supplements is now mainly derived from plant sources (see What It Does and Getting It from Food).
  • Do phophatidylserine supplements work?

    Although the FDA permits supplement labels to claim that phosphatidylserine may reduce the risk of dementia and cognitive dysfunction in the elderly, it also requires that such labels state there is little scientific evidence supporting this claim. Phosphatidylserine has also been studied in athletes but there is no strong evidence that it improves athletic performance (see What It Does).
  • Which phosphatidylserine supplement is best?

    ConsumerLab purchased and tested popular phosphatidylserine supplements and found that one contained only 10% of its listed amount (see What CL Found). (Update 1/11/24: Two lots of this product and a related product were subsequently recalled by the distributor after learning of our findings and confirming the problem in its own tests.) Other products passed testing, and none were contaminated with heavy metals (lead, arsenic, cadmium, and mercury) (see the Results Table). ConsumerLab selected two products as Top Picks for phosphatidylserine at a, respectively, moderate dose and higher dose based on demonstrated quality, source of ingredient, and cost.
  • How much phosphatidylserine should I take?

    The dose of phosphatidylserine taken in clinical trials has generally ranged from 200 mg to 800 mg daily, often divided into three doses taken with meals (see What to Consider When Using)
  • Safety and side effects of phosphatidylserine:

    Short-term studies with phosphatidylserine at the dosages noted above have generally reported it to be safe. It should be used with caution, however, by those on blood thinners or taking supplements with a blood thinning effect (see Concerns and Cautions)
Also see our review of phosphatidylcholine supplements, which is part of our Choline Supplements Review, and see our articles about supplements for memory and about two supplements that include phosphatidylserine: Neuriva and Qualia Mind.

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Alphabetical list of phosphatidylserine supplements compared in this review

View Larger Image Doctots_Best_Phosphatidyl_Serine_With_SerinAid-Phosphatidylserine-2023-small.png

Doctor's Best Phosphatidyl Serine With SerinAid

View Larger Image GNC_Phosphatidyl_Serine-Phosphatidylserine-2023-small.png

GNC Phosphatidyl Serine

View Larger Image Jarrow_Formulas_PS100-PhosphatidylserineJarrow_Formulas_PS100-PhosphatidylserineJarrow_Formulas_PS100-Phosphatidylserine-2023-small.png

Jarrow Formulas PS100

View Larger Image Life_Extension_PS_Caps_100_mg-Phosphatidylserine-2023-small.png

Life Extension PS Caps 100 mg

View Larger Image NOW_Phosphatidyl_Serine_300_mg-Phosphatidylserine-2023-small.png

NOW Phosphatidyl Serine 300 mg

View Larger Image Nutricost_Phosphatidyl_Serine-Phosphatidylserine-2023-small.png

Nutricost Phosphatidyl Serine

View Larger Image Puritans_Pride_Neuro-PS-Phosphatidylserine-2023-small.png

Puritan's Pride Neuro-PS

View Larger Image Swanson_Phosphatidylserine-Phosphatidylserine-2023-small.png

Swanson Phosphatidylserine

You must be a member to get the full test results along with's recommendations and quality ratings. You will get results for seven phosphatidylserine supplements selected for testing by as well as for one other product that passed the same testing in CL's voluntary Quality Certification Program. In this comprehensive review of phosphatidylserine supplements you'll learn:
  • Which phosphatidylserine supplements passed testing, and which failed
  • ConsumerLab's Top Picks among phosphatidylserine supplements
  • Which high-quality phosphatidylserine supplements are also lowest cost
  • What phosphatidylserine can and cannot do for your health based on clinical research, including information about its use for improving cognition and memory, and for exercise performance and recovery
  • What to look for on labels when choosing a phosphatidylserine supplement
  • The dosage of phosphatidylserine used in clinical trials and the best way to take phosphatidylserine
  • Safety, and potential side effects and drug interactions with phosphatidylserine

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Additional Information
Tested through CL's Quality Certification Program prior to, or after initial posting of this Product Review.