Are Pyruvate Supplements Helpful and Safe?

Medically reviewed and edited by Tod Cooperman, M.D.

Written by Meredith A. Worthington, Ph.D.

Published August 21, 2025

Answer:

Pyruvate is a molecule that occurs naturally in cells and is involved in energy metabolism. Due to this, pyruvate supplements have been promoted for weight loss and boosting athletic performance. Pyruvate also plays a role in the breakdown of fat, which is why it has been promoted for reducing cholesterol (Olek, Sports Med Health Sci 2024).

But do pyruvate supplements really work and are they safe?

Sign in as a member to learn about the clinical evidence for pyruvate supplements for weight loss, improving athletic performance, and lowering cholesterol levels. Also learn about the safety, side effects, and how to choose a pyruvate supplement.

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