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Only when taken at extremely high doses has melatonin has been reported to worsen symptoms of depression or to cause depression. For details, as well as information about other potential side effects of melatonin, see the Concerns and Cautions section of the Melatonin Supplements Review >>

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April 26, 2018

Have taken melatonin off and on many times and I find ABSOLUTELY leaves me feeling quite depressed. I have totally concluded it is not worth taking even at low dosages 300 mcg.
April 26, 2018

Thank you for sharing your experience with this, Michael.

April 30, 2018

ditto. and based on internet forums it seems we are not alone. i believe getting at least 20-30 minutes of sunlight early (esp around sunrise) the following morning can help minimize that or keep it at bay. i have found using only occasionally (and trying not to use consecutive days) also helps

July 11, 2021

My whole family independently discover the highly depressing effects of daily melatonin - over 1 mg a day. Three of the 5 discoveries of this negative effect were made absolutely independently.

November 29, 2017

I use a time-release Melatonin. Is it better or not
November 30, 2017

Hi Virginia - That depends on the nature of your sleep issue; please see the "What to Consider When Using" section and the Top Picks section of the Melatonin Review for more about this.

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