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Can Melatonin Cause Depression?

Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.
Initial Posting: 11/28/2017    Last Update: 11/28/2017

Question:
Can melatonin supplements cause depression or make depression worse?

Answer:
Only when taken at extremely high doses has melatonin has been reported to worsen symptoms of depression or to cause depression. For details, as well as information about other potential side effects of melatonin, see the Concerns and Cautions section of the Melatonin Supplements Review >>

Learn More About Melatonin Supplements



What is the best way to take melatonin to get a good night's sleep? >>

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I've heard that melatonin may increase the risk of broken bones. I take melatonin regularly. Should I be concerned? >>

I take melatonin to help me fall asleep. Are there any drugs that interact with melatonin that I should be aware of ? >>

Can melatonin help with stomach pain? >>

 See other recent and popular questions >>
COMMENTS
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Michael16763   April 26, 2018
Have taken melatonin off and on many times and I find ABSOLUTELY leaves me feeling quite depressed. I have totally concluded it is not worth taking even at low dosages 300 mcg.
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ConsumerLab.com   April 26, 2018
Thank you for sharing your experience with this, Michael.
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G16773   April 30, 2018
ditto. and based on internet forums it seems we are not alone. i believe getting at least 20-30 minutes of sunlight early (esp around sunrise) the following morning can help minimize that or keep it at bay. i have found using only occasionally (and trying not to use consecutive days) also helps
Comment on Post
Virginia16246   November 29, 2017
I use a time-release Melatonin. Is it better or not
Comment on Post
ConsumerLab.com   November 30, 2017
Hi Virginia - That depends on the nature of your sleep issue; please see the "What to Consider When Using" section https://www.consumerlab.com/reviews/melatonin-supplements/melatonin/#timedrelease and the Top Picks section https://www.consumerlab.com/reviews/melatonin-supplements/melatonin/#timedrelease of the Melatonin Review for more about this.
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This CL Answer initially posted on 11/28/2017.
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