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Do either phosphatidylserine or phosphatidylcholine help with memory and cognition? How are these supplements different?

Reviewed and edited by Tod Cooperman, M.D. cooperman.png

Initially Posted: 01/31/2017 | Last Updated: 08/28/2020

Answer:

There is little evidence that phosphatidylserine supplements sold today help improve memory or with Alzheimer's disease. In addition, it has been reported that many brands of phophatidylserine sold online do not contain their listed amounts of phosphatidylserine. Sign in and read the full answer for more information and details.

There is also not much evidence that phosphatidylcholine can improve memory or cognition. However, it does provide choline, which is a component of the neurotransmitter acetylcholine. Another chemical form of choline sold in supplements has shown some promise in improving memory and cognition as explained in the Choline Supplements Review (which includes our tests and comparisons of marketed supplements).

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4 Comments

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Loretta16882
June 4, 2018

Been taking PS almost 20 years. I'm 75, energetic and still work! Phosphatidylserine works for me, BUT only one brand, and one form.. SOFTGEL. Have tried many softgel brands but after a week I start to lose my memory.

Shaiele16889
June 8, 2018

Can you mention the brand you use? Thanks if you can.

micheline11646
February 1, 2017

I take phosphatidylserine at night to lower my morning cortisol and it works but didn't notice brain improvement.

J. M.12779
March 5, 2017

Like Micheline11646 I take phosphatidylserine to lower my cortisol levels. It was recommended to me by an integrative physician. However, I was told to take it in the early evening, around 6 p.m., to lower my evening cortisol levels so I would find it easier to rest in the evening. I was told cortisol is supposed to be higher in the mornings and mine is reversed where it raises in the evening instead of lowering.

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