Do either phosphatidylserine or phosphatidylcholine help with memory and cognition? How are these supplements different?

Answer:

There is little evidence that phosphatidylserine supplements sold today help improve memory in people with Alzheimer's disease or other forms of dementia, although they may provide limited benefit in people who already perform relatively well on the cognitive and memory tests. In addition, it has been reported that many brands of phophatidylserine sold online do not contain their listed amounts of phosphatidylserine. Sign in and read the full answer for more information and details, including examples of food sources of phosphatidylserine.

There is also not much evidence that phosphatidylcholine can improve memory or cognition. However, it does provide choline, which is a component of the neurotransmitter acetylcholine. Another chemical form of choline sold in supplements has shown some promise in improving memory and cognition as explained in the Choline Supplements Review (which includes our tests and comparisons of marketed supplements).