Initial Posting: 7/19/2015    Last Update: 8/14/2019
Answer: Hyaluronic acid is a natural component of cartilage and joint fluid. Some research suggests that hyaluronic acid supplements may be helpful for people with severe pain from knee osteoarthritis, and for people with knee osteoarthritis who are also overweight - although the evidence is limited to just a few small studies and not all have found a benefit. Be aware that hyaluronic acid is sometimes added to joint health supplements in amounts too small to have an effect, so if you want to try it, be sure your supplement provides an amount used in clinical studies. For more details, see the Hyaluronic acid section of theReview of Supplements for Joint Health. Also see our Top Picks among products.