BPC-157 and TB-500: Are These Compounds Safe and Effective Supplements?

Latest Update

TB-500 for Injury Recovery

Medically reviewed and edited by Tod Cooperman, M.D.

Written by Meredith A. Worthington, Ph.D.

Latest Update November 13, 2025 ⓘ

White capsules vials and a syringe on a blue background

Answer:

BPC-157 and TB-500 are both synthetic (laboratory-made) peptides that have been promoted for many uses: BPC-157 for improving bone and joint health, stomach ulcers, athletic performance enhancement, and anti-aging effects and TB-500 for wound healing, injury recovery, strength and endurance.

However, as we discuss, neither compound can be legally sold in the U.S. as an ingredient in dietary supplements and neither is approved as a drug, as there is a lack of human clinical research demonstrating their efficacy and safety.

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For information about supplements that have been investigated in humans for athletic performance and joint health, see our Reviews of Muscle and Workout Supplements, Collagen Supplements, Nitric Oxide Supplements, and Joint Health Supplements. Also, see our article about supplements for peptic (stomach) ulcers.

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