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The Difference Between CoQ10 and Ubiquinol

Question:
What is the difference between CoQ10 and ubiquinol?

Answer:
Only after you take CoQ10 (ubiquinone) does your body convert it to the active form, ubiquinol. Taking 100 mg of ubiquinol (sometimes labeled as CoQH-10 or CoQH2-10) compared to 100 mg of CoQ10, may yield a bit more active compound in your body. In short, you may be able to take a little less ubiquinol than CoQ10 to get the same result. 

However, more important than whether you take CoQ10 or ubiquinol is that fact that both are fat-soluble compounds, so to significantly improve their absorption, it is important to take them with a fatty meal or in a formula that contains fats or other solubility enhancers.

More information about CoQ10 and ubiquinol and their solubility-enhanced formulas is found in the CoQ10 and Ubiquinol Supplements Review, which includes our test results and quality ratings of dozens of products, as well as ingredient and price comparisons. See the CoQ10 and Ubiquinol Supplements Review now >>

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Learn More About CoQ10 and Ubiquinol:



What is "nano" CoQ10? Is it better than other CoQ10 formulations? >>

Are CoQ10 and ubiquinol safe to take for a long period of time? Should I give it a rest period? >>

Do CoQ10 levels really decrease with age? >>

Does CoQ10 reduce wrinkles, increase skin elasticity, or tighten the skin? Are there any other supplements that can help? >>

Can taking CoQ10 affect my thyroid levels or interact with my thyroid medication? >>

Can CoQ10 or ubiquinol be ruined by heat? I recently purchased several bottles of Qunol Plus from Costco.com and they arrived hot. The soft gels are not melted, but I am concerned. >>

What are CoQ10 side effects? >>



See other recent and popular questions >>
Comments
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Lynn16306   December 27, 2017
For a long time, I took 100 mgs of Ubiquinol CoQ10 and I still had low levels when I had my blood tested. These supplements are just too expensive to take more than 100 mgs so I resorted to the cheap 300mgs CoQ10 from Costco. For the first time, I had higher than normal levels of CoQ10. Ubiquinol, for me, was a waste of money.

Robert15223   June 28, 2017
I gave plain old uniquinone with no absorption enhancer to adults between 55 and 70 years old (unpublished study). I told them to take it with a meal that had at least 170 Calories from fat. After 9 days, plasma levels of CoQ10 increased substantially. I did not compare to any of the established enhanced CoQ10 products. However, the plasma values I got looked fairly close to what people report with the "super" CoQ10 products.

Dr Robert DiSilvestro, Ph.D.Biochemstry

Steven15229   June 28, 2017
What brand was it? jarrow sells powdered CoQ10 caps at a good price
Right now I'm taking Healthy Origins CoQ10 200 Mg. Was taking 100 Mg. before but the 200Mg. gives me more energy

I've tried Ubiquinol but for some reason it makes me feel strange

Jack272   November 24, 2014
What I wonder about is the quantity of CoQ10 to be taking and when. Most of the supplements in your review are 100 mg with recommendations of 1 to 3 a day. With the Costco 300 mg being "the most bang for the buck," I'm wondering if that's the "best" way for an 80 year old man to go. Are there any significant trade-offs between taking 100 mg 3 times a day versus the 300 mg once a day, so long as it's taken after a meal that includes a reasonable amount of fat?

ConsumerLab.com   November 28, 2014
Hi Jack - Interesting question! We've now answered it here: https://www.consumerlab.com/answers//coq10_dose_how_to_take/

mary16899   June 17, 2018
I would like to know if anyone has had severe lower abdomen pain with Swanson's Ubiquitol 200mg. Thank you.

ConsumerLab.com   July 16, 2018
Hi Mary - CoQ10 can cause gastrointestinal symptoms in some people, as noted in the "Concerns and Cautions" section of the CoQ10 and Ubiquinol Supplements Review (https://www.consumerlab.com/reviews/CoQ10-Ubiquinol-Supplements-Review/CoQ10/#cautions). However, if your pain is severe or persists, please consult with your physician.

mary16963   July 16, 2018
After switching from COQ10 to Ubiquinol, several weeks later I was having such lower abdomenal pain, it would take my breath away. This lasted everyday for several days, so the doctor sent me for diagnostic imaging and they found everything to be in good shape. It finally dawned on me that it could be the Ubiquinol, so I stopped it and within two days I was feeling so much better and having no pain. Feeling great now and went back to COQ10. Hope this helps you know that you are not alone.

This CL Answer initially posted on 8/5/2013. Last updated 8/8/2017.

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