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Alpha-Lipoic Acid Supplements Reviewed by


  • What is alpha-lipoic acid? Alpha-lipoic acid (or lipoic acid) assists in converting glucose into energy (See What It Is). A healthy body naturally produces enough alpha-lipoic acid but supplementation may help in certain situations.
  • What does alpha-lipoic acid do? Alpha-lipoic acid supplements may improve insulin sensitivity and blood sugar control, as well as reduce symptoms of peripheral neuropathy in people with type 2 diabetes. It may also increase weight and fat loss when combined with a low-calorie diet (See What It Does).
  • Which form of alpha-lipoic acid is best? Supplements contain synthetic versions of the naturally occurring form of alpha-lipoic acid (the R-isomer) or, more commonly, a mixture the R- and S-isomer forms. The R-isomer is the more active of the two isomers, however, only mixed forms have been studied for efficacy and side-effects in clinical trials and are generally much less expensive than R-isomer-only products. (See What to Consider When Buying).
  • How much alpha-lipoic acid should I take? The typical dose for treating diabetes, peripheral neuropathy associated with diabetes, and cardiac autonomic neuropathy is 200 to 400, taken 3 times daily (for a total daily dose ranging from 600 mg to 1,200 mg). For weight loss, 100 mg alpha-lipoic acid (taken three times per day with meals), along with a reduced-calorie diet, has shown to be beneficial. For use as a general antioxidant, a lower dose (20 to 50 mg daily) is commonly recommended (although there is no evidence this offers any health benefit). You may be able to halve the dose when using the R-isomer-only form (See What to Consider When Using).
  • Best choice for alpha-lipoic acid? Many products passed our tests of quality (See What CL Found). Among Approved products, identified several which represented its Top Picks.
  • Safety and side effects of alpha-lipoic acid: Side effects such as skin rash and nausea have been reported. Alpha lipoic acid may also contribute to acid reflux, as it is an acid. Because alpha-lipoic acid may help control blood sugar in diabetics, adjustments may be needed to anti-diabetic medication when using alpha-lipoic acid. Alpha-lipoic acid may interfere with thyroid function, medication and diagnostic tests. Although rare, alpha lipoic acid may cause insulin autoimmunity (See Concerns and Cautions).

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Alpha-lipoic acid supplements compared in this review

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alpha betic Alpha Lipoic Acid

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Bronson Laboratories Alpha Lipoic Acid

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Country Life R-Lipoic Acid

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GNC Alpha Lipoic Acid 600 mg

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Jarrow Formulas Alpha Lipoic Sustain 300 with Biotin

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Natrol Alpha Lipoic Acid 600 mg

Nature's Bounty Alpha Lipoic Acid

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Nature's Sunshine Alpha Lipoic Acid

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NOW Alpha Lipoic Acid

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Olympian Labs Incorporated Alpha Lipoic Acid Naturopathic 400 mg

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Ortho Molecular Products Lipoic Acid

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Pure Encapsulations Metabolic Xtra

Puritan's Pride Alpha Lipoic Acid 300 mg

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Radiance Platinum [CVS] Alpha Lipoic Acid

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Solgar Alpha Lipoic Acid 200 mg (200 mg per vegetarian capsule

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Spring Valley [Walmart] Alpha Lipoic Acid

Sundown Naturals Alpha Lipoic Acid

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TwinLab Alpha Lipoic Acid 100 mg per capsule

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Vitacost Alpha Lipoic Acid

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Vitamin World Alpha Lipoic Acid 200 mg

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Vitamin World Extra Strength Alpha Lipoic Acid

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Vitamin World Triple Strength Alpha Lipoic Acid

You must be a member to get the full test results along with's recommendations and quality ratings. You'll get results for 19 alpha-lipoic acid supplements -- 10 selected by and nine which passed testing in our voluntary Quality Certification Program, as well as information about three supplements similar to one that passed testing. 

In this comprehensive review, you'll discover: 
  • The best quality alpha-lipoic acid supplements and which passed or failed testing
  • Which alpha-lipoic acid supplements are the best value and are CL's Top Picks  
  • What alpha-lipoic acid can and cannot do for your health
  • How R-alpha-lipoic acid differs from mixed isomer alpha-lipoic acid
  • The dose of alpha-lipoic acid for specific uses   
  • Cautions when using alpha-lipoic acid, including side-effects, drug interactions, and interference with thyroid function, treatment, and tests (such as T3 and TSH)  

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Additional Information
Tested through CL's Quality Certification Program prior to, or after initial posting of this Product Review.