Is CBD oil (cannabidiol) effective and safe? Is it legal?
Learn more about cannabidiol (CBD), its potential effects, safety and side effects, and find out if CBD oils and pill are legal. ConsumerLab.com's answer explains.
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Our Members Asked:
Does CBD interact with other medications?
Reviewed and edited by Tod Cooperman, M.D.
Answer:
Yes. CBD (cannabidiol) can interact with other medications that, like itself, are metabolized in the body by the cytochrome p450 enzymes CYP3A4 and CYP2C19. By competing for these enzymes, CBD can reduce the metabolism of such drugs, raising their blood levels and possibly requiring downward adjustment of their doses. This has been seen in clinical trials in which hundreds of milligrams of CBD are given daily. The effect may be less pronounced with CBD supplements that provide smaller doses (single or tens of milligrams). For details and specific medications that may interact with CBD, see the Concerns and Cautions section of the CBD Oil and Hemp Extract Supplements Review.Join today to unlock all member benefits including full access to all CL Answers and over 1,300 reviews.
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Eileen17525
February 7, 2019What about CBD applied topically (like to an ankle) - any issues? recommended dosage?
ConsumerLab.com
February 14, 2019Hi Eileen - Please see the "Creams, gels and lotions" section of the CBD Oil Review: https://www.consumerlab.com/reviews/cbd-oil-hemp-review/cbd-oil/#topical
Jeffrey17520
February 6, 2019It seems the troubles may arise with large dosages. Not with something that has only 25mg of CBD ?
ConsumerLab.com
February 6, 2019Hi Jeffrey - As explained in the review ( https://www.consumerlab.com/reviews/cbd-oil-hemp-review/cbd-oil/#interactions) these effects appear to be dose-dependent, and it's possible that lower doses (e.g., 25 mg or less) would have more modest effects, but until more is known, it's best to be cautious.