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CBD Drug Interactions

Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.
Initial Posting: 2/5/2019    Last Update: 2/5/2019

Question:
Does CBD interact with other medications?
CBD (cannabidiol) drug interactions -- doctor holding bottle of CBD oil
Answer:
Yes. CBD (cannabidiol) can interact with other medications that, like itself, are metabolized in the body by the cytochrome p450 enzymes CYP3A4 and CYP2C19. By competing for these enzymes, CBD can reduce the metabolism of such drugs, raising their blood levels and possibly requiring downward adjustment of their doses. This has been seen in clinical trials in which hundreds of milligrams of CBD are given daily. The effect may be less pronounced with CBD supplements that provide smaller doses (single or tens of milligrams). For details and specific medications that may interact with CBD, see the Concerns and Cautions section of the CBD Oil and Hemp Extract Supplements Review.

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COMMENTS
Add Comment
Eileen17525   February 7, 2019
What about CBD applied topically (like to an ankle) - any issues? recommended dosage?
Comment on Post
ConsumerLab.com   February 14, 2019
Hi Eileen - Please see the "Creams, gels and lotions" section of the CBD Oil Review: https://www.consumerlab.com/reviews/cbd-oil-hemp-review/cbd-oil/#topical
Comment on Post
Jeffrey17520   February 6, 2019
It seems the troubles may arise with large dosages. Not with something that has only 25mg of CBD ?
Comment on Post
ConsumerLab.com   February 6, 2019
Hi Jeffrey - As explained in the review (https://www.consumerlab.com/reviews/cbd-oil-hemp-review/cbd-oil/#interactions) these effects appear to be dose-dependent, and it's possible that lower doses (e.g., 25 mg or less) would have more modest effects, but until more is known, it's best to be cautious.
Comment on Post

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This CL Answer initially posted on 2/5/2019.
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