Do any supplements help reduce menstrual pain or symptoms of premenstrual syndrome (PMS)?

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PEA for Menstrual Pain?

Written by Amy Malec — Medically reviewed and edited by Tod Cooperman, M.D.

Updated February 10, 2025 ⓘ

Woman in PJs Holding Stomach from Abdominal Pain

Answer:

Premenstrual syndrome (PMS) affects about 50% of women worldwide, and symptoms may include appetite changes, weight gain, pain in the abdomen and back, headache, breast tenderness, gastrointestinal issues, irritability, mood swings, and others (Gudipally, StatPearls 2023). Many supplements have been proposed to relieve these symptoms: Some appear to be helpful, while others are not, and at least one supplement may increase the risk of PMS.

Sign in as a member for details about the effects of calcium, chasteberry (Vitex agnus-castus), evening primrose oil, ginger, ginkgo, iron, magnesium, NAC (N-acetyl-cysteine), PEA (palmitoylethanolamide), potassium, royal jelly, vitamin B-6, and vitamin E, as well as the specific combination supplement Premen-Calm, on symptoms of PMS.

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