uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.


Supplement Interactions with Estrogen replacements


Estrogen replacement therapies, including oral forms as well as estrogen creams and vaginal tablets, such as Estrace, Imvexxy, Ogen, Premarin, and Vagifem, can be affected by certain supplements and foods. St. John's wort, and possibly quercetin, may decrease levels of these drugs, while grapefruit juice can increase levels (Vagifem Prescribing Information 2014; Premarin Prescribing Information 2018). Soy isoflavones have mild estrogenic effects and, theoretically, high doses could compete with estrogen replacement hormones for absorption.

Taking estrogen can also affect your ability to absorb certain vitamins and minerals, such as folate, vitamin C and zinc.

For more about dietary supplements for hot flashes, night sweats, and other menopausal symptoms, see the Menopause Supplements Review.

Join today to unlock all member benefits including full access to all CL Answers and over 1,400 reviews.

Join Now

Join now at

Loading Comments…