Does PrimeBiome Improve Aging Skin?

Answer:

PrimeBiome claims to "support the cell turnover process" to "help promote a more youthful appearance." However, PrimeBiome does not appear to have been evaluated in clinical studies for reducing wrinkles or aging skin, and there does not appear to be good evidence that its main ingredients are beneficial.

Read below for more details.

Also see our articles, "Do any supplements reduce wrinkles, increase skin elasticity, or tighten the skin?" and "Estrogen Creams for Wrinkles."

What Are the Ingredients in PrimeBiome?

ConsumerLab has not tested PrimeBiome, however, according to its label, each 1-gummy daily serving contains the following:

• 500 million CFU of Bacillus coagulans
• 430 mg of a Proprietary Blend containing chicory root inulin, babchi powder, fennel seed powder, fenugreek powder, ginger root extract, lemon balm leaf extract, lion's mane powder, slippery elm bark powder and dandelion leaf powder

A 1-gummy serving also contains 11 grams of carbohydrates (3 grams of sugar) and 45 calories.

Will PrimeBiome or Its Ingredients Improve Aging Skin?

There is no good evidence that PrimeBiome or its ingredients are beneficial for aging skin when taken by mouth daily in the amounts included in this supplement.

Bacillus coagulans is a probiotic that has been shown to improve wrinkles in a mouse model of aging skin (Hiramoto, Dermatopathology (Basel) 2023), but there does not appear to be any clinical evidence that taking Bacillus coagulans by mouth is beneficial for wrinkles in people. A clinical study among healthy women showed that applying a cream containing metabolites produced by Bacillus coagulans MTCC 5856 (LactoSporin – which is a postbiotic rather than a probiotic) daily for 10 weeks reduced wrinkles around the eyes or "crow's feet" compared to placebo cream (Majeed, Clin Cosmet Investig Dermatol 2023), but it is unclear if this benefit would be observed for cream or supplements containing Bacillus coagulans.

PrimeBiome also contains a proprietary blend of several "nourishing ingredients" that purportedly "supports beneficial bacteria" to "promote better skin health," but the amounts of the ingredients in this blend are not listed. As noted in our article, "8 Red Flags to Watch Out For When Buying Vitamins & Supplements," proprietary blends may contain very little of some of the ingredients included in the blend and, in some cases, there may be only shreds of evidence supporting the ingredients in the blend for its purported use.

As an example, the first ingredient listed in the blend (meaning it's included in the greatest amount) is chicory root inulin, a prebiotic. While there is evidence that another prebiotic called partially hydrolyzed guar gum (PHGG) might slightly improve skin elasticity compared to placebo, it is unclear if inulin has a similar benefit. Similarly, the second ingredient listed in the blend, babchi, is a source of the compound bakuchiol, which has retinol-like effects and has shown skin benefits when applied topically to the skin (Nizam, F1000Res 2023), but there does not appear to be evidence that bakuchiol is beneficial when taken by mouth, and it is unclear how much bakuchiol is in babchi in PrimeBiome. For many of the other ingredients in the blend — including fenugreek, fennel and ginger — there does not appear to be clinical evidence that these ingredients are beneficial for wrinkles when taken as a supplement.

How Much Does PrimeBiome Cost?

Compared to many other probiotic supplements, PrimeBiome is expensive. If purchased as a 180-day supply (6 bottles), which is promoted as the "Best Value," PrimeBiome costs $49 per bottle of 30 gummies ($1.63 per gummy). If purchased in a smaller quantity of only 60 servings (2 bottles), PrimeBiome costs much more: $79 per bottle ($2.63 per gummy)! This latter price per serving is more expensive than all of probiotics tested by ConsumerLab in 2024 and 2025.

The Bottom Line: Is PrimeBiome Worth It?

We don't think PrimeBiome is worth it's relatively high price of $2.63 per day as it does not appear to have been evaluated for improving skin health in any clinical studies, and there does not appear to be good evidence that its individual ingredients achieve this.