What is inositol hexaphosphate (IP6) and myo-inositol? Are they helpful in treating cancer or other conditions?

Answer:

Inositol hexaphosphate (IP6), more commonly known as phytic acid or phytate (the salt form), is a naturally-occurring compound. It is a source of phosphate in many plants and is abundant in foods such as cereals, grains and legumes.

IP6 is not digestible by people; in fact, it can chelate minerals in the gut, inhibiting their absorption.

A calcium-magnesium salt form of IP6 has been used in one preliminary study for treating type 2 diabetes, and IP6 has been used in combination with myo-inositol (also known as inositol) for reducing chemotherapy side effects. There is also one report of this combination used by a man with stage IV metastatic melanoma who, as reported by his doctors at the Mayo Clinic, entered remission.

Myo-inositol itself has been used for many other conditions, most notably polycystic ovary syndrome (PCOS), as well as depression, panic disorder and bipolar disorder, with some evidence of benefit.

Sign in for details about what these studies have shown, including information about dosage and safety, and learn how marketed form of inositol differ.

Note: Do not confuse inositol hexaphosphate with inositol hexanicotinate — a form of niacin found in some supplements.