Are Peptides Such as BPC-157 and TB-500 Safe and Effective?

Latest Update

FDA Panel Endorses Access to Peptides

Medically reviewed and edited by Tod Cooperman, M.D.

Written by Meredith A. Worthington, Ph.D.

Latest Update July 30, 2026 ⓘ

White capsules vials and a syringe on a blue background

Answer:

BPC-157 and TB-500 are both synthetic (laboratory-made) peptides that have been promoted for many uses based mainly on findings in animal studies: BPC-157 for improving bone and joint health, stomach ulcers, bladder pain, athletic performance enhancement, and anti-aging effects, and TB-500 for wound healing, injury recovery, strength and endurance.

However, as we discuss, neither compound can be legally sold in the U.S. or Canada as an ingredient in dietary supplements and neither is approved as a drug, as there is a lack of human clinical research demonstrating their efficacy and safety.

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For information about supplements that have been investigated in humans for athletic performance and joint health, see our Reviews of Muscle and Workout Supplements, Collagen Supplements, Nitric Oxide Supplements, and Joint Health Supplements. Also, see our article about supplements for peptic (stomach) ulcers.

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