Product Reviews and Information for Neuropathy
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Product Review
Alpha-Lipoic Acid Supplements Review
Choose the Best Alpha-Lipoic Acid Supplement — See the Amounts of Active "R-Isomer" We Found
CL Answer
Do any supplements, like Nervive, help with nerve pain, like sciatica, diabetic neuropathy or postherpetic neuralgia?
Find out which supplements for nerve pain, including fish oil and alpha-lipoic acid, are effective for sciatica, diabetic neuropathy, or postherpetic neuralgia.
Product Review
B Vitamin Supplements Review (B Complexes, B6, B12, Biotin, Folate, Niacin, Riboflavin & More)
See Our Top Picks and Which 5 Failed Testing
CL Answer
Is topical menthol, such as Biofreeze, safe and effective for pain relief?
Menthol is commonly used in topical creams and gels for pain relief. Find out if it works and if it's safe.
Product Review
Acetyl-L-Carnitine Supplements Review
Choose the Best Acetyl-L-Carnitine Supplement. Don't Overpay! CL Identifies Quality Acetyl-L-Carnitine Supplements at the Best Value.
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CL Answer
Does red and near infrared light therapy reduce pain, improve skin or cognition, or have other benefits? Is it safe?
Red light and near infrared light therapy devices are promoted for numerous conditions, including acne, fibromyalgia, pain, cognitive function and other uses. Find out if these devices work and if they are safe.
Product Review
Vitamin E Supplements Review
Find the Best Vitamin E Supplement. Tests and Reviews of Popular Vitamin E Supplements & CL's Top Picks.
CL Answer
What are the health benefits of palmitoylethanolamide (PEA), and is it safe?
Palmitoylethanolamide (PEA) is commonly promoted for its anti-inflammatory and pain-relieving effects. Find out if it works.
Product Review
Black Currant, Borage, Evening Primrose, Flax and Hemp Oil Review
Choose the Best Flaxseed and Other Oils Based on Our Tests.
Clinical Update
4/01/2015
Vitamin D for Diabetic Neuropathy
Supplementing with vitamin D can reduce pain and symptoms of diabetes-related peripheral neuropathy in people with type 2 diabetes who are vitamin D deficient, a recent study reports. More about the use of vitamin D in diabetes and many other conditions, as well as our product test results, are found in the Vitamin D Supplements Review >>
Clinical Update
1/31/2021
B12 for Diabetic Neuropathy?
Can high-dose vitamin B12 improve nerve function and reduce pain in people with neuropathy due to type 2 diabetes? See what a new study found in the B12 section of the B Vitamin Supplements Review. Also see our Top Picks for vitamin B12.
Clinical Update
1/04/2022
Vitamin D for Diabetic Nerve Pain?
Can vitamin D supplementation reduce nerve pain or other symptoms of peripheral neuropathy, such as numbness and tingling, in people with type 2 diabetes? See what a new study found in the Diabetes section of the Vitamin D Supplements Review. Also see our Top Picks for vitamin D.
For information about other supplements that may help, see our answer to the question: Do any supplements, like Nervive, help with nerve pain, like sciatica or diabetic neuropathy?
Clinical Update
6/17/2022
Lion’s Mane for Neuropathy?
Does supplementation with lion’s mane reduce symptoms of neuropathy? Find out what evidence suggests in our article about lion’s mane.
Also see our CL Answer about supplements for nerve pain.
Clinical Update
4/26/2024
Alpha-Lipoic Acid for Nerve Pain?
Is alpha-lipoic acid as effective as pregabalin (Lyrica) in reducing the pain of peripheral neuropathy? Learn what a recent study found in the What It Does section of our Alpha-Lipoic Acid Supplements Review, which includes our Top Pick for alpha-lipoic acid.
Also see: Do any supplements, like Nervive, help with nerve pain, like sciatica, diabetic neuropathy or postherpetic neuralgia?
CL Answer
L-Serine & D-Serine: Health Benefits and Safety
Serine exists in two forms: L-serine and D-serine. Find out how these two forms differ and learn if either form has health benefits and if it is safe.
CL Answer
Is P-5-P really better than "regular" vitamin B6?
Learn more about pyridoxal-5-phosphate (P-5-P) and vitamin B6.
CL Answer
Conolidine: Evidence for Pain Relief, Safety, and CONOCB2™ Products Explained
Find out if conolidine, the main ingredient in CONOCB2 Blend, offers natural pain relief without the side effects of opioids. Also learn about the top conolidine products available today.
Clinical Update
4/19/2024
Acetyl-L-Carnitine for Nerve Pain?
Is acetyl-L-carnitine recommended to reduce nerve pain in people with diabetes? Find out in the What It Does section of our Acetyl-L-Carnitine Supplements Review.
Also see: Do any supplements, like Nervive, help with nerve pain, like sciatica, diabetic neuropathy or postherpetic neuralgia?
Clinical Update
3/17/2025
Red Light Therapy for Nerve Pain?
Does red or near infrared light therapy reduce pain and improve sensation among people with diabetic or chemotherapy-induced peripheral neuropathy? Find out in our article about red and near infrared light therapy.
Clinical Update
5/19/2025
Melatonin for Nerve Pain?
Did taking melatonin reduce nerve pain? See what a recent study showed in the Other Uses section of our Melatonin Supplements Review.
Clinical Update
10/04/2022
Nerve Pain & Vitamin B-6
Vitamin B-6 deficiency can cause nerve pain and weakness, even resulting in inability to walk, as shown in a recent case. However, getting too much B-6 from supplements can also cause these symptoms. Find out how much B6 you should be getting in the Vitamin B-6 section of our B Vitamins Supplements Review.
For information about supplements that may help with other forms of nerve pain, see our answer to the question: Do any supplements, like Nervive, help with nerve pain, like sciatica or diabetic neuropathy?
Clinical Update
10/31/2023
PEA (palmitoylethanolamide) for Back Pain, Colds?
See the results of two recent clinical studies that evaluated PEA. One used PEA to treat low back pain/sciatica and the other to prevent or reduce symptoms of respiratory tract infections.
Also see: Do any supplements, like Nervive, help with nerve pain, like sciatica or diabetic neuropathy? and Do any supplements help prevent or treat a cold?
Clinical Update
1/03/2020
CBD Cream for Pain?
People suffering peripheral neuropathy in their legs and feet applied CBD cream or placebo for one month. Did it help? Find out in the Topical CBD section of our CBD Review. Also see our Top Picks among creams, oils, and other CBD products.
Clinical Update
8/14/2021
Danger With Too Much B-6
A CL member recently told us about a friend who developed progressively worsening neuropathy (nerve damage) after taking very high dose vitamin B-6. It's important to be aware of the upper daily limit for vitamin B-6 and that taking too much can cause nerve damage, as well as skin lesions and other adverse effects, as discussed in detail in our B Vitamin Supplements Review.
Product Review
Lion's Mane and Chaga Supplements Review
Read Labels Carefully -- Many Can Mislead
Product Review
Melatonin Supplements Review
Trouble Sleeping? See CL's Tests of Melatonin Supplements and Top Picks.
CL Answer
Do supplements help with Parkinson’s disease treatment or prevention?
Learn what has been shown with vitamins D and E, niacin, CoQ10, melatonin, creatine, SAMe, NAC, valerian, CoQ10, and CBD, as well as with coffee and the Mediterranean and MIND diets for treating and/or preventing Parkinson's disease.
CL Answer
Can taking too much vitamin B-6 be dangerous?
Find out if multivitamins contain excessive amounts of B-6, how much B-6 is too much, and symptoms of toxicity and overdose.
News Release
January 23, 2025
ConsumerLab Tests Identify Best Black Currant, Borage, Evening Primrose Flax and Hemp Oils
White Plains, NY, January 23, 2025 — Black currant, borage, evening primrose, flax, and hemp oils contain omega-3, -6, and/or -9 fatty acids that, when replacing saturated fats in the diet, may help reduce cardiovascular risk.
CL Answer
Supplements for multiple sclerosis (MS): Do any supplements reduce symptoms or relapse?
Find out if vitamins or supplements such as ginkgo, fish oil, biotin, vitamins A, C, E, D, and B12, or selenium reduce symptoms or relapse in people with multiple sclerosis (MS).
CL Answer
I thought the B vitamins were all water soluble and did not build up in the body, so you would not build up toxic levels. Am I wrong?
Learn more about water-soluble B vitamins including niacin, B6, B12 and folic acid, and why taking too much of these vitamins can be toxic. See the symptoms of overdose and toxicity from B vitamins. ConsumerLab.com's answer explains.
Product Review
Vitamin D Supplements Review (Including Calcium, Magnesium, Vitamin K, and Boron)
Find the Best Vitamin D Supplement and Avoid Problems
Recalls & Warnings
July 06, 2022
Two Companies Banned From Selling Supplements to Treat Heart Disease, Neuropathy
On June 30, 2022, the Federal Trade Commission (FTC) finalized an administrative complaint order against two Texas-based companies, Health Research Laboratories, LLC and Whole Body Supplements, LLC, for making unverified claims that their products can prevent or treat disease.
CL Answer
I take levothyroxine (Synthroid), a thyroid hormone to treat hypothyroidism. Are there supplements or foods I should avoid, or be taking, due to this drug?
Is taking certain supplements and hypothyroidism medications bad? Learn which supplements can interact with thyroid hormone medications like levothyroxine (Synthroid), thyroid hormone levels, and laboratory tests.
Product Review
CBD Oils, Softgels, Gummies, Creams & Salves Review
See How Much CBD and THC We Found in Products.
CL Answer
Do detox foot pads or ionic foot baths remove heavy metals or other toxins from the body?
Detox foot pads and ionic foot baths are promoted for removing heavy metals and other toxins from the body. Find out if there is evidence to support these claims.
News Release
August 09, 2023
ConsumerLab Tests Alpha Lipoic Acid Supplements and Selects Top Picks
White Plains, New York, August 9, 2023 — Alpha-lipoic acid supplements may modestly improve insulin sensitivity and blood sugar control, reduce symptoms of peripheral neuropathy, and aid in weight control when combined with a low-calorie diet.
News Release
October 06, 2022
Lion’s Mane and Chaga Supplement Labels May Mislead, According to ConsumerLab Tests
White Plains, New York, October 6, 2022 — Lion’s mane and chaga supplements are often promoted to improve memory and mood, boost the immune system, and a range of other health benefits.
CL Answer
I take omeprazole (Prilosec), a proton pump inhibitor, to reduce stomach acid. Are there supplements I should avoid, or be taking, due to this drug?
Supplement interactions with proton pump inhibitor (PPI) drugs like omeprazole (Prilosec) and Nexium.
Recalls & Warnings
April 24, 2023
FTC Warns Almost 700 Companies: Unsupported Health Claims May Result in Substantial Civil Penalties
On April 13, 2023, the Federal Trade Commission (FTC) notified approximately 670 companies that market over-the-counter (OTC) drugs, homeopathic products, dietary supplements, or functional foods that they could incur significant civil penalties if they make unsubstantiated claims about the ...
News Release
November 27, 2017
Flaxseed and Other Popular Omega 3 & 6 Oil Supplements Tested, But Not All Brands Pass -- Tests of Black Currant Oil, Borage Oil, Evening Primrose Oil, Flaxseed Oil, and Hemp Oil Supplements
White Plains, New York, November 27, 2017 — Flaxseed oil and other popular seed oil are popular supplements that provide omega-3 and omega-6 fatty acids and may help with inflammatory conditions. But which seed oil supplements are the best? To find out, ConsumerLab.
CL Answer
Do any supplements, foods, or oils help reduce muscle pain, muscle cramps, or nighttime leg cramps?
Find out which supplements, and topical products such as magnesium creams, can help reduce muscle pain, leg cramps, and nighttime leg cramps, and which may worsen muscle cramps. Also, learn about vitamin and mineral deficiencies and common medications that can cause muscle cramps and nocturnal leg cramps.
News Release
December 06, 2016
Which Brands of Alpha Lipoic Acid are Best? -- ConsumerLab.com Tests Lipoic Acid Supplements for Quality, Identifying Top Picks
White Plains, New York, December 6, 2016 — Alpha-lipoic acid supplements may improve insulin sensitivity and blood sugar control in people with type 2 diabetes, reduce symptoms of diabetic peripheral neuropathy, and enhance weight loss when dieting.
News Release
January 11, 2011
Spoilage and labeling errors found with some omega-3 and -6 supplements; Review of evening primrose, flaxseed, borage, and black currant oil supplements
WHITE PLAINS, NEW YORK — JANUARY 10, 2011 — A new report on the quality of omega-3 and -6 fatty acid supplements made from seed oils was released by ConsumerLab.com today. Only 11 of 17 products selected for testing met quality criteria for freshness and labeling.
Recalls & Warnings
November 20, 2020
FTC Files Complaint Against Two Supplement Companies for Deceptive Marketing
On November 20, 2020, the FTC approved a Part 3 administrative complaint against Health Research Laboratories, LLC, its owner Kramer Duhon, and Whole Body Supplements, LLC for making unverified claims that their products can prevent or treat diseases.
Recalls & Warnings
February 24, 2023
Bountiful Charged with “Review Hijacking,” False Advertising of Nature’s Bounty Supplements on Amazon
On February 16, 2023, the Federal Trade Commission (FTC) charged The Bountiful Company (formerly NBTY), whose brands include Nature’s Bounty and Sundown, with deceptively using Amazon reviews and badges (such as “#1 Best Seller” and “Amazon’s Choice”) from its ...
CL Answer
What are trace minerals and do I need them?
Trace minerals include boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, zinc, and others. Find out what they do, how much of each trace mineral you should be getting, and who's most likely to be deficient in these minerals.
Recalls & Warnings
April 25, 2020
Injectable Curcumin, CBD Are Not Safe, Warns FDA
On April 9, 2020, the FDA issued a warning letter to BIOTA Biosciences LLC following a review of the company's website, which found statements made about some of the company's, products, including Canabidiol (CBD) Complex, Cannabidiol+Curcumin, and Curcumin Complex to be ...
Recalls & Warnings
May 24, 2013
Maker of Neuropathic Pain Product Warned For Drug Claims, Misbranding
On April 11, 2013, the FDA issued a warning letter to Realm Labs, LLC, following a review of the company’s websites which found statements made about its NeuRemedy products to be drug claims.
News Release
October 07, 2009
ConsumerLab.com finds that only two-thirds of alpha-lipoic acid supplements selected for testing pass quality review -- Anti-oxidant supplements helpful to diabetics
White Plains, New York — Wednesday, October 7, — Alpha-lipoic acid (also called lipoic acid) is a natural anti-oxidant that can help diabetics reduce symptoms of peripheral neuropathy and control blood sugar, among other uses. ConsumerLab.
News Release
May 15, 2007
ConsumerLab.com finds some alpha lipoic acid supplements come up short — Improper formulation may cause ingredient degradation
WHITE PLAINS, NEW YORK — May 15, 2007 — ConsumerLab.com announced that two of eleven alpha lipoic acid supplements that it recently chose to test contained significantly less ingredient than promised on their labels.
News Release
August 31, 2005
ConsumerLab.com testing of alpha lipoic acid supplements from Japan finds no ingredient in one product; Most others meet claims — Japanese consumers urged to research product quality
WHITE PLAINS, NY — ConsumerLab.com reported this week that among nine brands of alpha lipoic acid supplements it recently purchased in Japan and tested, one contained none of the popular ingredient and another contained only 81%.
News Release
December 20, 2004
Testing of Alpha-lipoic acid supplements by ConsumerLab.com finds most meet label claims but one with only 15% of ingredient — Antioxidant of potential benefit in diabetes and other conditions
WHITE PLAINS, NY — December 20, 2004 — ConsumerLab.com announced today that one of 21 alpha-lipoic acid supplements recently tested contained only 15% of the alpha-lipoic acid that it claimed. Alpha-lipoic acid is an antioxidant naturally produced in the body.
Recalls & Warnings
October 18, 2017
Total Body Nutrition Warned for Banned Stimulant in Supplements
On September 28, 2017, the FDA issued a warning letter to Total Body Nutrition following a facility inspection which found some of the company's products to be adulterated because they were prepared, packed, or held under conditions that violate Current Good Manufacturing Practices for dietary ...
Recalls & Warnings
April 26, 2013
Seller of Immune, Cholesterol, Liver and Blood Sugar Products Warned For Drug Claims
On March 20, 2013, the FDA issued a warning letter to Birkdale Medicinals LLC, following a review of the company's website which found statements made about Birkdale products, including Immune Response 247, Cholestat, Silymarin 81 and LevelStat, to be drug claims.
