Product Reviews
SAMe (S-adenosyl-methionine) Supplements Review

Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.
 Initial Posting: 1/16/16  Last Update: 3/14/20
Sam-e supplements reviewed by

Choose the Best SAMe Supplement

CL Tests Reveal Big Differences in Quality and Cost

SAM-e supplement brands compared in this review
Cellfood SAM-e Liquid Formula Nature Made SAM-e Complete Spring Valley [Walmart] SAMe
CVS pharmacy SAM-e Nature's Sunshine SAM-e Swanson Ultra High-Potency SAMe
Designs For Health SAMe Nature's Trove SAMe 400 mg The Vitamin Depot Double Strength SAM-e
Doctor's Best Double-Strength SAMe NOW SAMe Vitacost SAM-e
GNC SAM-e RiteAid Pharmacy SAM-e 200 mg  
Cellfood SAM-e Liquid Formula CVS pharmacy SAM-e Designs For Health SAMe Doctor's Best Double-Strength SAMe GNC SAM-e Nature Made SAM-e Complete Nature's Sunshine SAM-e Nature's Trove SAMe 400 mg NOW SAMe RiteAid Pharmacy SAM-e 200 mg Spring Valley [Walmart] SAMe Swanson Ultra High-Potency SAMe The Vitamin Depot Double Strength SAM-e Vitacost SAM-e
Make sure the SAM-e supplement you take passed our test and quality rating and is right for you!
Isn't your health worth it?
SAM-e is involved in many functions in the body and, as a supplement, has been shown to be helpful in reducing the pain of osteoarthritis as well as improving mood in major depression. But which SAM-e supplements are best? selected 10 SAM-e supplements and tested them to see whether they contained their claimed amounts of SAM-e, and if the enteric coatings (which protect SAM-e in the stomach) worked properly. One product was discovered to contain only 77% of its listed SAM-e.

SAM-e can be expensive, with products costing as much as $3 per day. Among the products which passed testing (including three products tested through CL's voluntary Quality Certification Program), CL determined which provided the best value. It found three products which passed all tests and provided 400 mg of high-quality SAM-e for as little as 51 to 63 cents. In addition, each was enteric-coated to protect SAM-e from stomach acids and sold in blister packs to prevent spoilage from moisture, as SAMe is a sensitive compound.

In this comprehensive review of SAM-e (also called SAMe, S-adenosyl-methionine, or S-adenosyl-L-methionine) supplements, you'll get test results and quality ratings for 13 SAM-e supplements. You'll learn:
    • Which SAM-e supplements passed or failed testing 
    • Direct comparisons and quality ratings of SAM-e supplements, including cost comparisons showing you can pay anywhere from 51 cents to over $3 for the same amount of SAM-e -- it pays to compare prices  
    • What SAM-e can and cannot do for your health
    • Tips on buying SAM-e and how to properly store it
    • SAM-e dosage for different conditions
    • Concerns, drug interactions, and potential side-effects of SAM-e 

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Learn More About SAMe supplements Answers -- for SAMe (S-adenosyl-methionine) Supplements Review
Are enteric coated supplements better than non-enteric coated ones? Get the answer >>

I take fluoxetine (Prozac), a SSRI drug to treat depression. Are there supplements I should avoid, or be taking, due to this drug? Get the answer >>

I've read about several different forms of SAMe. Is one form better than another? Get the answer >>

Is Rhodiola rosea effective for depression and does it have other uses? Will be testing these supplements? Get the answer >>

My dog is getting older and his veterinarian recently recommended giving him a glucosamine supplement for his joints. Has tested these, or other supplements for pets? Get the answer >>

I take a supplement containing a "proprietary formula" which lists many ingredients. Can ConsumerLab test the contents so I'll know the amounts of each ingredient? Get the answer >>

Is it best to take SAMe with or without food? Do I need to take B vitamins when taking SAMe? Get the answer >>

Which supplements help for osteoarthritis of the hip? Get the answer >>

What are the best supplements for depression and anxiety? Get the answer >>
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