
Answer:
Although ashwagandha supplements (typically taken for anxiety or stress) are generally well-tolerated when taken short-term (weeks to a few months) in typical dosages, mild to moderate side effects such as headache, sleepiness, and stomach upset have been reported in clinical studies (Ramakanth J Ayurveda Integr Med 2016; Chengappa, J Clin Psychiatry 2018). Rarely, liver injury, allergic reactions, and rapid heartbeat have been reported (Philips, Hepatol Commun 2023; Ireland, J R Coll Physicians Edinb 2021; Weber, Am J Gastroenterol 2021; Bjornsson, Abstract in Gastroenterology 2019; Dwivedi, Trop Doct 2011). Ashwagandha can potentially lower blood pressure and blood sugar, and increase thyroid hormone levels (Gannon, J Ayurveda Integr Med 2014; Andallu, Indian J Exp Biol 2000; Panda, J Pharm Pharmacol 1998). Ashwagandha might also stimulate the immune system, which might decrease the effects of immunosuppressant drugs, trigger organ transplant rejection, and induce symptoms of autoimmune diseases (Norris, American College of Physicians Annual Scientific Meeting 2018).
There are no long-term studies on the safety of ashwagandha supplements, and they should not be used by women who are pregnant or nursing.
See the Concerns and Cautions section of the Ashwagandha Supplements Review for more details about the ashwagandha's side effects. The Review includes ConsumerLab's tests and reviews of popular ashwagandha supplements, its Top Pick, and the evidence regarding ashwagandha for anxiety, physical and cognitive performance, and other uses.
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Judy22828
May 23, 2025Since I started taking ashwagandha again, I noticed my sleep was more restless. I read that it can interfere with sleep in some people when taken close to bedtime. Has this happened to anyone here and has CL found as an adverse reaction in their research? I was taken a Now 450 mg. standardized extract in a capsule with dinner.
We are not aware of any published reports of ashwagandha causing insomnia.
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Hanna22034
February 21, 2025I have celiac disease, an autoimmune disorder. Apparently, ashwagandha is not recommended for people with autoimmune diseases.
Thank you for sharing your experience. We have updated the Concerns and Cautions section of our Ashwagandha Supplements Review to include information about ashwagandha and autoimmune conditions: https://www.consumerlab.com/reviews/ashwagandha-supplements/ashwagandha/#autoimmune-conditions
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Barron10521
January 06, 2024I would like to take ashwagandha occasionally but the fact that it completely fries some people's liver is just too scary of a proposition. and of course I realized that millions of people have probably taken ashwagandha but still if you're one that get your liver fried you are in big trouble
As noted in the Concerns and Cautions section of our Ashwagandha Supplements Review, toxicity is rare and seems to be of greatest concern for people with preexisting liver disease https://www.consumerlab.com/reviews/ashwagandha-supplements/ashwagandha/#liverinjury-update.
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Miriam10518
September 01, 2022I have a terrible time staying asleep. I usually wake up 2-3 times per night. Sometimes I wake at 2:00 AM and can’t go back to sleep at all. I have Afib and take Eliquis. Is Ashwaganda safe for me?
As noted in the Concerns and Cautions section of our Ashwagandha Supplements Review ( https://www.consumerlab.com/reviews/ashwagandha-supplements/ashwagandha/#cautions), it's possible that ashwagandha could affect heart rhythm and therefore may be a concern for people with atrial fibrillation. It might also have a blood-thinning effect and should be used with caution in people taking blood thinners.
victoriak
January 27, 2023I have a difficult time staying asleep as well and have been taking holy basil extract (Gaia brand, 1 dose (40 drops)). It has worked better for me than Benadryl or Ambien. I take it in the evening and it doesn't really make me tired, yet somehow I sleep more soundly at night than I have in a long time. I don't know whether it's safe with your Afib & meds, but you may want to discuss with your doctor. Please see ConsumerLab review of holy basil extract. I have no financial interest in Gaia.
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Cindy10517
March 25, 2022I recently started taking an Ashwagandha supplement that also contains Rhodiola, vitamin D, Magnolia and L-Theanine… my negative thoughts have subsided and I feel lighter than I have in years; sleep like a baby with a little help from 5mg Melatonin…it was suggested by a functional medical / acupuncturist…
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denise10516
February 23, 2022Thank you for this article. I began taking it at the advice of my doctor as a sleep aid. Curiously I get a lot less sleep on this supplement, but the worrying concern is that it spiked my hyperthyroid levels so I was advised to increase my thyroid medication, which didn't make me happy.
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DAROLYN10515
November 18, 2021I am 68. Seven years ago, my husband died and I was plunged into a world of grief, depression, anxiety & insomnia. I had never had any of these problems before and after 4 years I was tired of it, so I began to take Ashwagandha to see if it might help me. After some research, I bought "Physician's Choice Ashwahandha 1950 mg." The dosage is 3 capsules, but I never took more than one a day. After about 6 months, my depression, and all other symptoms were gone and I felt "normal" again. I have been taking this product daily before bedtime for the last 3 years with NO side effects whatsoever. (I do not have any allergies to anything.) My anxiety & insomnia disappeared and I fall asleep almost immediately. My doctor runs a full panel of blood tests on me every year and everything is normal. My cholesterol, triglyceride, and glucose levels are also normal as are my liver enzymes (I have NASH - nonalcoholic steatohepatitis). Physician's Choice also makes an Ashwahgandha KM 66 product, but that one is not for anxiety & depression; it seems to be more for physical endurance, which I don't need. I have no financial interest in the above mentioned company, I just wanted to comment that Ashwahgandha has been great for me.
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Lindsley10511
August 16, 2020I take an Ashwagandha extract for sleep. It is as powerful as the 15mg dose of temazepam I occasionally take. If I take 2 of either, I feel drugged and my memory is poor the next day. In fact, for a while I felt that the Ashwagandha was making me depressed, so I no longer take it nightly. The extract is considerably more powerful than the “whole” Ashwagandha capsules I used to take. I treat the extract with caution, as I do any prescription drug, but it is helpful with my insomnia (I fall asleep easily but awaken later and can’t return to sleep. I have sleep hypopnea, use a CPAP.)
Craig Osborne
January 04, 2022It's been quite a while since you posted this so I wonder c how you situation has improved? My situation c is very much the same. Looking for relief from insomnia and that awful CPAP doesn't help with undisturbed sleep!
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Susan10509
August 16, 2020I have taken ashwagandha for 2-3 months at a time a number of times. I really like it, it deepens my sleep, boosts my physical strength and endurance and lifts mood. I have no side effects but I read that it is likely to accentuate the effect of any other drug you take.
Please see the Concerns and Cautions section of the Ashwagandha Supplements Review for information about drug interactions https://www.consumerlab.com/reviews/ashwagandha-supplements/ashwagandha/#cautions.
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wayne10505
January 08, 2020I have a violent reaction to ashwaganda, vomiting and diarrhea. Lasts for hours, recently had the same reaction to powdered supplement that did not have ashwaganda listed as an ingredient but was made in the same facility that produced supplements with ashwaganda. Suspect cross-contamination.
Simona10506
October 17, 2020Wayne 18825. I had exactly the same reaction as you. First time I took one pill I felt vague stomach distress later. l asked myself if my distress was from the supplement. The next time I took one tablet I’d eaten Taco Bell food at about 2am. I ate, still couldn’t sleep, so took one ashwaganda pill. Next morning I was very sick and blamed it on food poisoning. A week or so later I took just one pill again. My results were the same: extreme nausea, sick, gagging, vomiting and diarrhea. I am not a weak tummied vomiting type person! Clearly, though, I must be more allergic to ashwaganda than anything I’ve ever eaten/taken before. I can’t recall the name brand but it’s in a chunky square container sold at Costco. The label has a white background. The maker has one or more other items sold at Costco in nearly the same color and block shape container. I considered complaining to Costco. Instead just tossed the container and forgot. Seeing your comment- maybe I will notice Costco after-all.
Judy21909
February 07, 2025I have tried ashwaganda twice…several years apart. Both times I became violently ill with vomiting and diarrhea that lasted 2-3 hours. Now I have to check ingredients on supplements as many manufacturers are adding it to other products.
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Jeanette17
November 03, 2019I found ashwagandha very helpful for sleep and anxiety. However, it made me break out on my face. At first it was after 3 or 4 days, so I started taking it every other day. Within a week, I was breaking out whenever I took it - even if I waited a week in between doses.
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Jean10499
February 10, 2019I tried using Ashwaganda 3 different times, but gained unwanted weight each time. I wonder if anyone else has had this problem.
I have no financial interest in this product or competing product.
Lawrence10501
October 16, 2019I have taken the so-called best Ashwaganda products off and on for years, guided by Consumerlab picks and at high and low doses. I have never felt anything from it.
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alma10497
January 08, 2019I have been on Lisinpril for many years, I love vitamins but not sure which ones I can take while on lisinipril. Could you please advice me? I dont know the interactions.
Hi Alma - Please see our CL Answer about supplement interactions with Linsinopril and other ACE inhibitor drugs: https://www.consumerlab.com/answers/which-supplements-should-be-avoided-when-taking-ace-inhibitors/ace-ihibitor-interactions/.
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Lida10495
December 22, 2018I could benefit from taking ashwaganda to help with stress and anxiety but wonder if it can be taken alongside baby aspirin if taken hours apart?
Hi Lida - Some preliminary research suggests ashwagandha may have blood-thinning effects, so use with caution if taking aspirin. See the "Concerns and Cautions" section of the Ashwagandha Supplements Review: https://www.consumerlab.com/reviews/ashwagandha-supplements/ashwagandha/#cautions.
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Candance10493
December 12, 2018I have always been able to take ashwagandha in the whole herb form as a tincture or powdered. But, I purchased a recommended brand, and took it for 3 days. On the third day (today), I broke out into hives with itching, and also had a huge blood sugar drop. I felt absolutely awful. I thought I was going to faint. That was earlier in the day. I am still feeling quite out of it, and have a headache. I do not have any financial interest in the product.
Hi Candance - Thank you for sharing your experience with this. Ashwagandha can cause allergic reactions, including rash and itching, and may potentially lower blood sugar, as noted in the Concerns and Cautions section of the Ashwagandha Review: https://www.consumerlab.com/reviews/ashwagandha-supplements/ashwagandha/#cautions. Also be aware that extracts are more potent than whole-herb products.
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Diana10492
September 21, 2018I have no financial interest in the product noted, but I can say when I take Ashwaganda I feel great and have better outlook on life! I have social anxiety and it helps me cope somehow someway. I have never taken it long term, but have been taking it for the last month and a half (250 mg - at night to help with sleep). I am not certain it makes a huge difference with sleep as I take Trazadone, but I can say I wake up pretty refreshed and feeling great! I also have hypothyroid and take 1 grain Naturethroid. My levels are always on the lower side, but my ND tells me they are good. It could help me in that area too, but everything is trial and error and how you feel so for now I like it and will keep taking it!
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Linda10491
September 10, 2018I discontinued my dessicated thyroid pills on my own and have used Ashwagandha tincture so I can control the amount I take to assist my thyroid. I use it once daily for 3-4 weeks at a time then stop for a few weeks before restarting. My thyroid levels are in the "normal" range but on the edge. I take the tincture with water as directed about 5 hours before bed. If you have had problems, I support not using it again because herbs, etc. can be very powerful and have unwanted side effects depending on the individual. Based on my own experience, I will no longer try any herb in capsule form. I have no financial interest in this supplement.
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Stephanie10489
August 24, 2018Each of the three times I took a supplement that had ashwaghanda in it, I thought that I was having a heart attack. Heartbeat was so rapid.
I have no financial interest in this supplement.
Connie10490
September 04, 2018What other ingredients were in these supplements? That could make a big difference.
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wayne10481
August 22, 2018Don't know how common it is but I get a violent reaction to ashwaganda, vomiting and diarrhea, generally feeling like I'm at death's door for a few hours. Needless to say I avoid it like the plague.
Robert10487
July 30, 2019I had the same reaction to ashwagandha as wayne 17096 August 22, 2018, I went to the ER for non-stop dry heaves and diarrhea later. They measured lipase extremely elevated in my blood test. I emptied the jar of ashwaghanda down the toilet and flushed it. Never again!
Diane10488
September 20, 2019How much were you taking and was it an extract form?
Sara10483
October 13, 2019When I tried ashwaghanda, I had severe pain in one knee that had never bothered me before. My husband suspected it may be in the night shade plant family. It is. Those sensitive to this plant family need to be aware. It includes popular vegetables - white potato, tomatoes, peppers, egg plant , gogi berries, goose berries and ashwaghanda. Tobacco is also a nightshade plant. I stopped using ashwaghanda and the pain went away. I'm leaving this herb out of my diet for the rest of my life.
Hi Sara - Thank you for sharing this. Ashwagandha is part of the "nightshade" family of plants, and, as noted above, could potentially cause allergic reactions in some people. You can find more about this in the "Concerns and Cautions" section of the Ashwagandha Supplements Review: https://www.consumerlab.com/reviews/ashwagandha-supplements/ashwagandha/#cautions.
Regina10482
September 05, 2021I also had a violent response from taking ashwagandha. I don.'t recall the details, but it was my digestive system. I have never had a response like that before Genie Deutsch
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