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Our Members Asked:
Best Supplements to Prevent Age-Related Muscle Loss

Answer:
After age 30, adults may lose between 3% to 8% muscle mass each decade, and the rate of muscle loss may accelerate after age 60 (Volpi, Curr Opin Clin Nutr Metab Care 2018). Age-related muscle loss (the progressive loss of skeletal muscle mass and strength) may increase the risk of falls and has been associated with increased mortality (Clynes, Calcif Tissue Int 2015).
Some supplements may help to slow the loss of muscle as we age, although some have shown benefit only if combined with resistance exercise, and not all supplements promoted for slowing muscle loss seem to help.
Sign in as a member for details about supplements that may help and some that might not. Supplements discussed include branched-chain amino acids, creatine, fish oil, hydroxymethylbutyrate, protein powders and shakes, urolithin A, ursolic acid, and vitamin D.
In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:
- Aguiar, Res Sports Med 2022
- Apaydin, BMC Endocr Disor 2018
- Bear, Am J Clin Nutr 2019
- Bhasin, JAMA Int Med 2018
- Bislev, Calcif Tissue Int 2018
- Bislev, Nutrients 2020
- Cangussu, Osteoporos Int 2015
- Cione, Clin Nutr ESPEN 2021
- Clynes, Calcif Tissue Int 2015
- Courel-Ibáñez, Nutrients 2019
- Da Boit, Am J Clin Nutr 2016
- English, Am J Clin Nutr 2016
- Katashima, Obes Rev 2017
- Lobo, Biomed Pharmacother 2022
- Lobo, Clin Nutr 2021
- Mori, Geriatr Gerontol Int 2018
- Oktaviana, J Nutr Health Aging 2019
- Volpi, Curr Opin Clin Nutr Metab Care 2018
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Latest Research Updates (Clinical Updates)
Ursolic Acid for Slowing Muscle Loss?
February 10, 2025
Protein for Older People?
February 03, 2025
Does supplementing with protein lead to greater muscular benefits in older people involved in resistance training? See what a recent review of studies concluded in the Building and maintaining muscle mass section of our Protein Supplements Review, which includes our Top Picks among protein powders, shakes, and drinks.
Also see: Best Supplements to Prevent Age-Related Muscle Loss
Shatavari for Strength?
January 23, 2025
Did taking shatavari (wild asparagus) help increase muscle strength in women doing resistance training in a recent study? Find out in the Shatavari section of our Menopause Supplements Review.
Also see our article: Best Supplements to Prevent Age-Related Muscle Loss
HMB for Muscle Loss With Age?
September 03, 2024
Also see our Top Picks among muscle & workout supplements.
Supplements for Muscle Loss?
August 26, 2024
Related CL Answers (9)
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The "Updated" date indicates when new information was most recently added to this article. In the full article, the newest information is highlighted in yellow.
Jean21883
February 04, 2025Are there any studies in humans using Ursolic Acid to retain muscle mass in the elderly? It is supposed to be in apple skins, rosemary, plumes, etc.
We've added information about ursolic acid for reducing age-related muscle loss to the following section of our article: https://www.consumerlab.com/answers/best-protein-to-gain-and-maintain-muscle/best-protein-for-muscle/#ursolic-acid
Reply to this post…
Rita20823
October 08, 2024I want to know the best way to get high-quality protein from whole FOOD, not from supplements.
Thank you for your question. You can find information about getting high-quality protein from food in the following article: https://www.consumerlab.com/answers/getting-high-quality-protein-from-food/complete-protein-from-food/
Reply to this post…
Lulu
April 09, 2024What is the more beneficial- a regular collagen supplement or an amino acid supplement?
This is discussed in our Collagen Supplements Review. Please see https://www.consumerlab.com/reviews/collagen-supplements-review-peptides-hydrolysate/collagen/#muscle.
Reply to this post…
Evan10902
May 04, 2020It would be helpful to have tips on how to better absorb protein. Older adults don't always benefit from the protein we eat. I'm 63 years old with a very healthy moderately-high-protein diet, plus I take 10 grams a day free form amino acids. My latest blood work showed low Total Protein, even though kidneys and liver seem to be healthy. I also take betaine HCl and enzymes at each meal.
Please see the ConsumerTips section of the Protein Supplements Review https://www.consumerlab.com/reviews/protein-powders-shakes-drinks-sports/nutritiondrinks/#hudson.
Reply to this post…
Glenn10891
November 13, 2019When you state that "Plant-based foods can also provide protein and build muscle, although, individually they might not provide the optimum ratio of amino acids," you are dangerously close to repeating the now debunked myth that vegans and vegetarians must "combine" various proteins to get a "complete" protein profile. Credible studies exist on this topic:
https://nutritionfacts.org/2018/12/20/do-you-have-to-combine-plant-proteins-at-a-meal/
https://www.huffpost.com/entry/vegetarian-protein-complete-meat_n_5a90357ae4b01e9e56bb3224
I am a 69 year old man (6' 3", 185 lbs), and strive to eat a plant-based diet except for fish and occasional eggs. I consume 90-110 grams of protein a day; much of it from whole foods but with some augmentation from Garden of Life Organic Plant Based Protein (no financial interest). I also engage in relatively heavy weight training 3 days a week. I am easily able to maintain strength and considerable muscle mass. I consider the regimine a fountain of youth and highly recommend it to older folks.
Hi Glenn - As noted by Eve (below), you do need to get all the essential amino acids (which may require a combination of plant-based foods) but you don't need to get them all in the same meal. What we have written about this is correct.
Bruce10894
December 30, 2019I will be 69 in about two weeks. I am training with weights 5 times per week with a personal trainer and training pretty hard. I am getting muscle definition which I found somewhat surprising. I like I am 30 years old again. No aches, no pains.
I am 5 ft 7 in and 192 lbs. I have 30 more pounds to lose to reach my ideal weight.
josephine10895
December 29, 2019I’m glad this individual has found a plan that works well for him.
Many of us have chronic kidney disease and therefore protein intake is limited; before following the above recommendations please know at least the results of the following blood tests: BUN, Creatinine and glomerular filtration rate. Anemic individuals w/ hypertension often have chronic kidney disease.
Pharmacist Barry
April 12, 2020I thought that plant based protein
Would not impact those with kidney disease I would like to hear from an MD or RD
Hi Barry - If you need to limit protein intake, the source of the protein (meat or vegetable) would not seem to matter.
Rebecca10892
December 29, 2019Glenn18639, I totally agree with you on plant based protein. I am almost 59 years old and have not eaten any red meat, poultry or pork in over 3 years. I occasionally eat fish and some shrimp. My blood work and my body have never been so good.
Reply to this post…
eve10888
November 13, 2019as i understand it, it doesn't matter if you have all the essential amino acids at once as long as you get them all and a whole food plant-based diet provides them all. btw, and soy provides all the essential amino acids.
You can learn more about soy and thyroid hormones here https://www.consumerlab.com/answers/do-any-supplements-interfere-with-thyroid-hormones/hypothyroidism-and-supplements/.
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joanne10886
August 25, 2019How about the bone broth protein powders?
Hi Joanne - Please see the Bone Broth Review for information and our tests of bone broth protein powders: https://www.consumerlab.com/reviews/bone-broth-review/bone-broth/#results.
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Kathy10883
August 12, 2019Do you test protein powders that are sold directly from distributors like Usana, Shakeology, Shaklee, Plexus, Isagenix etc.?
Hi Kathy - We do test products made by these companies, but we have not tested protein powders from each. You can use our site search to see which Reviews contain products from each brand.
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Cecelia10881
May 26, 2019For many years I have been making my breakfast smoothie with Natures Plus Unsweetened Gluten Free High Protein Energy Meal. All ingredients and digestive enzymes are listed. I am pre-diabetic but adding some frozen blueberries and small medium banana with CocoVia dark chocolate powder make a great shake. I purchase the powder from VitaCost.
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Jeffrey10875
March 09, 2019I like to take Swanson Vitamin's organic pea protein powder along with its Green Max mixed in. They are inexpensive and don't taste bad or overly sweet like other brands. I use a small, inexpensive, high powered battery powered whisk from Amazon that takes double A batteries to whip it up quickly.
Lech10876
April 30, 2019Very good! I like this. I think we should be wary of animal protein in general given not-so-recent developments.
I still have two bags of whey which I will finish, but I am transitioning to a vegan diet and will probably begin to experiment with plant protein if I cannot manage with just whole food (although lentils e.g. are delicious and have a good amino acid profile).
There are top weight lifters and athletes on vegan diets so it's certainly possible to achieve good results without animal protein. The only question is how easy it will be without supplements :-/
Reply to this post…
Jane10859
February 27, 2019Here's a good resource to double check your protein powder.
https://www.cleanlabelproject.org/protein-powder/
Hi Jane - As noted in our Protein Powder Review, the Clean Label Project identified any "detectable" amount of heavy metal. Since the danger of heavy metals is a function of dose, it is important to look at the levels found relative to known limits, which is what what we did in our report: https://www.consumerlab.com/reviews/protein-powders-shakes-drinks-sports/nutritiondrinks/#cleanlabelproject
Jane10861
March 04, 2019Thank you for clarifying this - I stopped using protein powders b/c they all seem to upset my stomach - I'm using goat milk kefir as a base for my smoothies and its been working great. Thanks for all the great research you guys do!
You're welcome Jane, and thank you for your kind words. We are glad to hear you are enjoying ConsumerLab!
Stomach upset can be an issue for some people when consuming protein powders and drinks ( https://www.consumerlab.com/reviews/protein-powders-shakes-drinks-sports/nutritiondrinks/#concerns) so others may appreciate your solution.
You can also find information about kefir in the Probiotics Review ( https://www.consumerlab.com/reviews/probiotic-supplements/probiotics/#whatitis).
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