Magnesium plays an important role in brain cell function and some preliminary research in animals has suggested it may influence cognitive functions like memory and learning.

Increasing magnesium intake may improve cognition in older people who otherwise have a high ratio of calcium to magnesium intake.

A preliminary study in people found that magnesium-L-threonate (Magtein or Clarimem) modestly improved limited aspects of cognitive function. Another study of magnesium-L-threonate in people with dementia was completed in mid-2016 but the results have not been published.

For more information, see the Dementia and cognition section of the Magnesium Supplements Review.

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MAX 8032
November 4, 2015

Magnesium Oil topically applied to the body will stop restless legs. This is my personal experience.

June 7, 2015

Wei's retracted article concluded that " Our results suggest that elevation of brain magnesium exerts substantial synaptoprotective effects in a mouse model of AD and may have therapeutic potential for treating AD in humans."

However the retraction stated that " we discovered errors in the quantification of the expression and/or phosphorylation of a subset of signaling pathways, particularly related to Figures 4 and 5D. Despite these errors, the major conclusions of the paper remain substantiated. "

So it appears there are two rat model studies supporting this supplement...

It's unfortunate that the human study is overdue...

November 27, 2019

Just the Magnesium Oxide has changed my life because it works great for anxiety. I am 75. I don’t care about the looser bile effects. I sleep better and I am not as anxious and so I am not as forgetful.

August 30, 2020

I started taking Magtein (magnesium threonate) a couple of months ago and I've found that it definitely improved my short term memory, and I can remember more of my dreams now. I usually only take 1/3 of the recommended dose. I am a 69 year old male in excellent health with a big-time sweet tooth.

September 10, 2020

The sweet tooth is a problem. My doctor says simply, "sugar shortens life".

Sugar generates a lot of free radical stress and is inflammatory.

Sugar feeds cancers.

Sugar sets up adrenaline roller-coasters. (Sugar causes the release of adrenaline, which is why sugar can trigger heart arrhythmia.)Your bowel flora population is very likely skewed by your sugar habit, and thus your sugar eating bowel flora may be crying out for yet more sugar, causing you to crave it. Sugar causes the overgrowth of candida (yeast) in the gut. Consider using probiotics and pre-biotics and diet, to try to set your bowel flora straight. Foods like artichokes encourage the growth of good gut flora. Consider eating plain live yogurt. I have read that a dose of l-glutamine will kill sugar cravings. L-glutamine can be bought in quantity on the internet as pure powder The dosing instructions should be on the package. You need to lose your sugar habit.
September 28, 2020

Thank you Patricia for sharing your experience. In addition to there being evidence that high blood sugar levels have been linked with age-related memory decline (, there is also evidence that high intake of refined sugar can negatively affect gut flora ( Probiotics have been shown to help restore balance to the gut flora through various mechanism (see our Probiotics Supplements Review for more details:, and some evidence suggests certain probiotics might have some benefit on cognitive function in people with Alzheimer's disease (, although more research is needed. Despite anecdotal evidence, there is no good data from clinical trials supporting the use of probiotics or L-glutamine for reducing sugar cravings.

January 17, 2020

Have been taking Magnesium L-Threonate for a few months now especially treating Lethologica. It works, but I noticed that it does only when I take the full 2,000 mg (4 capsules), not less.

June 15, 2020

Thank you, AMI19025.I didn't know the word for my curse. I'll use your dosage. :)

July 30, 2018

Just a personal experience. I have never been able to do oral Mg supplements as they trigger diarrhea. I tried many different ones, including Magbrite or some such that promised money back if side effects. I was using the external Mg solution but hated the sticky, burning feel of it. I have been doing the Mg threonate for about 3 years with no diarrhea and an unexpected but noticeable improvement in lethologia--having difficulty with recalling words and with short-term memory. As a teacher (age 77), I have been pleasantly surprised by this effect, which was not the reason I began using this type of Mg.

August 11, 2019

What dose are you taking?

April 2, 2017

following up on my previous comment. results of the study should be available in 2018. in the mean time my mother, who has alzheimer's, is taking the study dose daily.

November 27, 2016

magtein a brand of magnesium l-threonate is currently being studied for use in mild/moderate dementia.

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