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Magnesium plays an important role in brain cell function. Adequate intake of magnesium (from the diet and/or supplements) may optimize cognitive function and reduce the risk of developing dementia, as suggested by several studies. However, getting too much magnesium is not beneficial, and no form of magnesium has been proven to be better than others at crossing the blood-brain barrier to enter brain — although some forms of magnesium are better absorbed than others from the gut.

For more details, including results of studies with magnesium L-threonate (sold as Magtein and in the product Clarimem), see the Dementia and cognition section of the Magnesium Supplements Review.

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August 30, 2020

I started taking Magtein (magnesium threonate) a couple of months ago and I've found that it definitely improved my short term memory, and I can remember more of my dreams now. I usually only take 1/3 of the recommended dose. I am a 69 year old male in excellent health with a big-time sweet tooth.

September 10, 2020

The sweet tooth is a problem. My doctor says simply, "sugar shortens life".

Sugar generates a lot of free radical stress and is inflammatory.

Sugar feeds cancers.

Sugar sets up adrenaline roller-coasters. (Sugar causes the release of adrenaline, which is why sugar can trigger heart arrhythmia.)Your bowel flora population is very likely skewed by your sugar habit, and thus your sugar eating bowel flora may be crying out for yet more sugar, causing you to crave it. Sugar causes the overgrowth of candida (yeast) in the gut. Consider using probiotics and pre-biotics and diet, to try to set your bowel flora straight. Foods like artichokes encourage the growth of good gut flora. Consider eating plain live yogurt. I have read that a dose of l-glutamine will kill sugar cravings. L-glutamine can be bought in quantity on the internet as pure powder The dosing instructions should be on the package. You need to lose your sugar habit.
September 28, 2020

Thank you Patricia for sharing your experience. In addition to there being evidence that high blood sugar levels have been linked with age-related memory decline (, there is also evidence that high intake of refined sugar can negatively affect gut flora ( Probiotics have been shown to help restore balance to the gut flora through various mechanism (see our Probiotics Supplements Review for more details: and some evidence suggests certain probiotics might have some benefit on cognitive function in people with Alzheimer's disease (, although more research is needed. Despite anecdotal evidence, there is no good data from clinical trials supporting the use of probiotics or L-glutamine for reducing sugar cravings.

January 17, 2020

Have been taking Magnesium L-Threonate for a few months now especially treating Lethologica. It works, but I noticed that it does only when I take the full 2,000 mg (4 capsules), not less.

June 15, 2020

Thank you, AMI19025.I didn't know the word for my curse. I'll use your dosage. :)

July 30, 2018

Just a personal experience. I have never been able to do oral Mg supplements as they trigger diarrhea. I tried many different ones, including Magbrite or some such that promised money back if side effects. I was using the external Mg solution but hated the sticky, burning feel of it. I have been doing the Mg threonate for about 3 years with no diarrhea and an unexpected but noticeable improvement in lethologia--having difficulty with recalling words and with short-term memory. As a teacher (age 77), I have been pleasantly surprised by this effect, which was not the reason I began using this type of Mg.

August 11, 2019

What dose are you taking?

April 2, 2017

following up on my previous comment. results of the study should be available in 2018. in the mean time my mother, who has alzheimer's, is taking the study dose daily.

November 27, 2016

magtein a brand of magnesium l-threonate is currently being studied for use in mild/moderate dementia.

MAX 8032
November 4, 2015

Magnesium Oil topically applied to the body will stop restless legs. This is my personal experience.

Gale 23144
August 8, 2021

I tried Magnesium Oil plus many other "remedies" on foot affected by Plantar Fasciitis. Some helped a bit, but I got immediate pain relief using inexpensive "HEELTHATPAIN" Rubber Heal Seats in both shoes. Improved posture right away, too. I have no interest whatsoever in Amazon or any other company that sells or manufactures heel seats. I'd just suffered for months from Fasciiis --and find it so amazing I can now walk normally without pain using this product! Hope this can help other fasciitis sufferers.

The Pure Encapsulations Magnesium Citrate I've taken for over 30 years has been helpful, but considering switching to Magtein based on info here. Thanks, ConsumerLab!

June 7, 2015

Wei's retracted article concluded that " Our results suggest that elevation of brain magnesium exerts substantial synaptoprotective effects in a mouse model of AD and may have therapeutic potential for treating AD in humans."

However the retraction stated that " we discovered errors in the quantification of the expression and/or phosphorylation of a subset of signaling pathways, particularly related to Figures 4 and 5D. Despite these errors, the major conclusions of the paper remain substantiated. "

So it appears there are two rat model studies supporting this supplement...

It's unfortunate that the human study is overdue...

November 27, 2019

Just the Magnesium Oxide has changed my life because it works great for anxiety. I am 75. I don’t care about the looser bile effects. I sleep better and I am not as anxious and so I am not as forgetful.

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