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PQQ Supplements and How They Compare With CoQ10 -- woman holding two supplement bottles


Both PQQ (pyrroloquinoline quinone) and CoQ10 (ubiquinone) are antioxidant compounds used by the body, but they differ in many ways and, unlike CoQ10, which has been extensively researched in well-controlled clinical studies, only a few, small and relatively short clinical studies have been conducted with PQQ. These studies have focused on the effects of PQQ on memory and cognition, cholesterol levels, energy and mood, athletic endurance, body composition and inflammation.

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July 6, 2020

I tried PQQ a couple of years ago, decided it was a waste of money for me. I’m now considering trying it again, taking it with a fatty meal as suggested here.

May 24, 2020

These comments fascinate me. I have or am taking this (and other things) but I never feel any effects whatsoever from anything I take. I do sometimes track time I have taken things too to make sure I have given enough time for effects. Zero. The only thing I can add is after getting violent Hypnic headaches for years they stopped. Your guess may be as good as mine as to which supplement has stopped them.
Violent vomiting, then dry heaving with a headache beyond description, leaving me exhausted and weak.
It may be as simple as a good multi B vitamin.

January 19, 2020

My liver always showed signs of stress according to my labs until I started 20mg/day of PQQ. My labs have been perfect ever since, baffling my doctor. I tried to explain how this happened but I think it may have gone over her head. She'd never heard of PQQ.
February 6, 2020

Hi Kiel - We've added information about PQQ and liver disease/damage in the answer above.

August 1, 2020

What brand did you use?

August 13, 2019

When I started PQQ at a 10 mg dosage, I had a very mild pressure in the center of my forehead just above the eyes but no pain. I was never sure it improved cognition or memory, but I had a very noticeable increase in physical energy. Over time, the effect lessened, and upped the dosage to 20 mg. About the same results but an overall decline in energy. People suggest cycling off and on, but I like energy every day.

August 15, 2018

Natural Factors makes a 20 mg PQQ plus 200 mg Co-Q10 softgel. I take one a day with a meal that contains fat and have noticed quite an improvement.

June 28, 2021

An improvement in what?

January 15, 2018

I used to get debilitating headaches within half hour after taking this supplement (20 mg). The headaches stopped after I stopped taking it. I'm considering trying a lower dose: 10 mg or lower if I can find it.

August 6, 2019

Do you have a history of migraines? I want to try PQQ but I get migraines and I'm now worried PQQ may trigger migraines.

Pamela 18225
August 21, 2019

I get migraines and had a problem on 20mg but when Inreduced the dose they went away. A weight/dose chart I found on line indicated 10mg was the appropriate dose for me.

December 25, 2017

Please review some PQQ products that contain also Ubiquinol!

This has a high PQQ and Ubiquinol to Price ratio:

Jarrow Formulas, Ubiquinol, QH+ PQQ, 30 Softgels or 60 Softgels.

At least if you look at iherb prices

January 10, 2018

I also am interested in knowing test results of Ubiquinol +PQQ from Jarrow. I’ve read that Ubiquinol is much better absorbed than Ubiquinone, especially as one ages, but don’t know how valid that assertion is.
January 10, 2018

Thank you for your suggestion Angelika. Please see this CL Answer about the difference between CoQ10 and ubiquinol, and more about their absorption:

November 23, 2017

I am extremely fond of all the advice, accuracy and sound information found on this highly rated website. Please keep us all apprised and once again Thanks!!!

August 13, 2017

Thanks for the article. Perhaps this particular quinone will upstage CoQ10 (ubiquinone)? It seems possible, judging from the many studies on PQQ linked on PubMed, where PQQ is shown to enhance mitochondrial function. Since mitochondria are found in nearly every human cell, I hear that mitochondria influence metabolism, heart health, brain health and risk for cancer. I greatly look forward to Consumer Lab's test of PQQ supplements! I am eager to purchase some, but I always like to consult your database first. Thanks!

April 23, 2017

same comment but i am 83, also seem to have more energy

October 19, 2016

Have no financial interests in this or any other competing product(s). Have been taking P.Q.Q. for one month. Perhaps it's a placebo effect that explains the following comment, but I'm 65 years old and I've been ... introduced ... to mild "brain fog." I do believe this supplement has helped me in terms of better concentration. Feel less distracted. Once again, my report is strictly anecdotal, but for now, I'm staying with this product. I'll report (positively or negatively) if and when any changes occur.

May 8, 2017

Alan11348 -- My husband's brain scan shows amyloid plaques and he is receiving two rx Alzheimer drugs that have only short term effect in slowing the process. He's 72 and quite highly functioning but the senior moments -- hard recalling names of people and places instantly although the data show up after 20-30 minutes, etc. -- are present.

Anything further to report after six months on PQQ?

December 26, 2018

In terms of treating Alzheimer’s disease, I, personally, have found “The End of Alzheimer’s “ by Dale Bredesen, MD very helpful. Excellent book, written by a neurologist who specializes in this area. He mentions a number of supplements.

May 30, 2019

Thanks for the tip—-I just ordered the book from Amazon.

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