Initial Posting: 11/29/2013    Last Update: 8/8/2017
Answer: Fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil) and other selective serotonin-reuptake inhibitor (SSRI) drugs can be affected by taking supplements and can affect your ability to absorb certain vitamins and minerals. Certain herbal supplements, such as St. John's wort and Garcinia cambogia (HCA), may increase the risk of serotonin syndrome associated with SSRIs. Other supplements, like 5-HTP, and SAMe, may also increase this risk.
On the other hand, folic acid, a B vitamin, may be beneficial for some people taking an SSRI.
These interactions are explained in the SSRIs article, which is part of the extensive Drug Interactions section of our website (where you can look up interaction for other drugs you may be taking).