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Yes, certain supplements may increase or decrease the effectiveness of clopidogrel (Plavix). This can increase the risk of bleeding or, conversely, increase the risk of blood clots. Clopidogrel is a "prodrug," meaning it must be broken down by the body to become active. Two liver enzymes, CYP3A4 and CYP2C19, are responsible for this. Consequently, supplements that inhibit these enzymes may reduce the effectiveness of clopidogrel, while supplements that that induce these enzymes may increase the activity of clopidogrel. Certain beverages and foods may also affect this drug.

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