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Our Members Asked:
Which supplements and lifestyle changes improve sleep, and which cause insomnia?

Answer:
Supplements including melatonin, tart cherry juice extract, L-tryptophan and 5-HTP, L-theanine, CBD (cannabidiol), ashwagandha, glycine, saffron, valerian, and possibly magnesium, lemon balm (e.g., Relissa and Cyracos), or Prevagen may, to varying degrees, improve sleep. Various lifestyle modifications, including avoiding the use of digital devices before bedtime and possibly listening to music before bed, might also help.
On the other hand, some supplements, especially energy drinks, weight loss supplements, and cocoa products, as well as red yeast rice, garlic, policosanol, DHEA, chromium and high doses of vitamin D, vitamin b-12, potassium and coenzyme Q10 might interfere with sleep. In some cases, adjusting dosing or timing of dose may help.
What you eat may also affect your sleep.
Sign in as a member for more information, including evidence about multivitamins, fish oil, GABA, calcium, vitamin K, prebiotics, protein supplements, and cucumber extract (Q-actin), as well as traditional remedies for insomnia such as drinking chamomile tea or inhaling lavender oil.
In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:
- Cases, Med J Nutrition Metab 2010
- Chen, J Am Geriatr Soc 2021
- Di Pierro, Nutrients 2024
- Gangwisch, Am J Clin Nutr 2019
- Hieu, Phytother Res 2019
- Kaur, StatPearls 2022
- Lloyd, Front Nutr 2025
- Pierre, Platelets 2005
- Schwartz, Perioper Med (Lond
- Segal, CMAJ 2006
- Shinomiya, Biol Pharm Bull 2005
- Srivastava, Mol Med Report 2010; McKay, Phytother Res 2006
- Trabace, J Ethnopharmacol 2015
- Tu, Addict Behav 2023
- Viola, Planta Med 1995
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Related Reviews (6)
Latest Research Updates (Clinical Updates)
Cucumber Extract for Sleep?
May 22, 2025
Lemon Balm for Sleep?
December 09, 2024
Casein for Sleep?
November 18, 2024
Did Lactium, a branded casein, help people with insomnia fall asleep faster or improve sleep quality? See what a recent study found in the Casein section of the Protein Supplements Review, which includes our Top Picks among protein powders.
Also see: Which supplements and lifestyle changes improve sleep, and which cause insomnia?
Magtein for Sleep?
September 09, 2024
Also see: Which supplements and lifestyle changes improve sleep, and which cause insomnia?
Best Source of Collagen?
September 09, 2024
Chamomile and Bleeding Risk?
January 23, 2024
Smartphones & Sleep
August 04, 2023
Does turning off your smartphone a few minutes before bedtime help improve sleep quality? See what a recent study showed in the Lifestyle modifications section of our article about improving sleep.
Is Chamomile Tea Safe?
November 18, 2022
A CL member asked if chamomile tea is safe to drink. It’s generally safe in moderation, but there are concerns with drinking large amounts and with regular consumption during pregnancy. For details, see the Chamomile tea section in our CL Answer about supplements for improving sleep.
Music for Better Sleep
August 19, 2022
Can listening to music before bedtime improve sleep quality? Find out what research suggests in our updated CL Answer about supplements and lifestyle interventions for sleep.
Glycine for Sleep?
August 02, 2022
Does taking glycine improve sleep and, if so, at what dose? Find out in our CL Answer about supplements for insomnia.
Chamomile for Sleep?
July 26, 2022
A CL member asked us if chamomile tea is helpful for insomnia. See what research suggests, and learn about potential interactions with chamomile, in our updated answer to the question: What are the best supplements for insomnia? Are there any supplements that interfere with sleep?
Related CL Answers (1)
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Ratings of ConsumerLab
The "Updated" date indicates when new information was most recently added to this article. In the full article, the newest information is highlighted in yellow.
Linda23360
July 20, 2025Lemon balm 400mg. twice daily did help me sleep ....but then it stopped working.
Reply to this post…
Linda22907
June 01, 2025Coconut oil whether internally or on the skin, gives me insomnia. Everything has coconut oil in it...food, detergents, hand soap, make up..you name it.
Thank you for sharing this. We are not aware of any published reports of coconut oil causing insomnia.
Reply to this post…
FloridaFamilyOf3
June 01, 2025I wake up every night at 3 a.m. for no reason I can pinpoint. I fall asleep easily, it's staying asleep which is the challenge. I eat dinner at 6 p.m. and fall asleep around 11:30p.m. so I don't think it's dinner timing / digestion related. It's not too much water before bed, either. This only started happening a few months ago.
Andrew23306
July 16, 2025Similar pattern to mine, in retirement. So most nights I need not worry about messing up my schedule of activities. I fall asleep exhausted, wake up about 2-3 hrs later, then do things I enjoy quietly at home. As the 2nd bedtime approaches, I take sometimes take some supplements: tryptophan, valerian, melatonin, magnesium threonate, apigenin.
Reply to this post…
Jessica22536
April 16, 2025Great info! Does anyone have any experience or insights from taking lemon balm?
Jody A22825
May 23, 2025It did Not help me at all.
Reply to this post…
fang20224
July 28, 2024I recommend people with poor sleep quality to try NAD+ IV infusion. A dose of 250mg had an immediate effect on me. After the first infusion, I had a sweet dream for the first time in a long while, felt very energetic all day, and was in a great mood.
Thank you for sharing. Unfortunately, there is no good clinical evidence that IV vitamin infusions provide health benefits except in specific therapeutic situations — such as treating vitamin or mineral deficiencies, and they can be unsafe. See our article about intravenous (IV) vitamin infusions for details: https://www.consumerlab.com/answers/are-iv-vitamin-infusions-safe-and-beneficial/iv-vitamin-infusion/
Reply to this post…
Glenn9918
January 16, 2024Has anyone tried Lysine for sleep? I'm wondering exactly how it affects the cortisol level, which may be off with some people.
Thanks for your question. Please see our Lysine Supplements Review for details about lysine for sleep: https://www.consumerlab.com/reviews/lysine-review-comparisons/lysine/#sleep
Glenn18664
February 08, 2024In reviewing the study linked in your lysine review for the cortisol level effect (reference https://pubmed.ncbi.nlm.nih.gov/17510493/), I see that the study abstract states "we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in MALE subjects." The study summary doesn't state that its study of "one hundred eight healthy Japanese adults" excluded women, so based on this brief study abstract, is one to presume that the women's cortisol levels are not affected by lysine supplementation?
And, for any CL member out there who's female, did you find that taking lysine helped with your sleep quality? If so, in what respect?
In the study that included healthy Japanese adults (https://pubmed.ncbi.nlm.nih.gov/17510493/), L-lysine supplementation affected salivary cortisol levels in only men. There was no significant change in salivary cortisol levels in women.
Reply to this post…
Joshua9915
July 25, 2023I found that 200 mg of magnesium glycinate makes me calm and decreases my anxiety a lot. I take Thorne powder ( no financial interest).
You can find information about magnesium supplementation and anxiety in the "What It Does" section of our Magnesium Supplements Review https://www.consumerlab.com/reviews/magnesium-supplement-review/magnesium/#anxiety.
Reply to this post…
Betty9907
July 25, 2023As a lifetime dieter, I have found over and over and over that reduced calories or reduced carbs cause insomnia. Wake up at 2am and it takes hours to get back to sleep. As soon as my calories go back to a normal level and/or I eat a high carbohydrate diet my sleep is great again. This is very common amongst those of us who are always trying to watch our weight.
Gretchen9912
October 15, 2023Same here.
Claudia9911
November 10, 2023It is exactly the same for me, If I wake up at night and can't go right back to sleep, eating a carb snack usually is a big help.
Rebecca9910
November 15, 2023If I can't fall asleep I will eat a small bowl of low-sugar granola with milk. It works 99% of the time.
barbara9909
November 16, 2023If I'm too hungry I wake up in middle of night. Sometimes protein shake works. Sometimes I need a little more like nutrigtain bar.
Denise18865
February 27, 2024Same here with consuming a small bowl of cereal with unsweetened almond milk! Also, sometimes 2 scrambled eggs with cheese and raisin toast will put me to sleep as will an 8oz steak from meat market!! No financial interest in any product mentioned. My comments based upon the experiences of myself and others in my household!!
ruth19714
June 15, 2024Same here
LayPerson
December 22, 2024ditto.
A calm audiobook can sometimes help, too.
Sarah22829
May 23, 20253/4 cup of warm, frothed milk (L-tryptophan) works for me!
Reply to this post…
Sean9902
May 25, 2023Melatonin worked great for me at first but by the 3rd day I started to build a tollerance to it and had to take more. After about 5 or 6 days I stopped, and had a harder time than usual falling asleep for the next 2. Which for my body's effects it seemed to build dependence on it very quickly. Now I avoid it.
As we note in the following section of our Melatonin Supplements Review, some people may experience a loss of response to melatonin but, in such cases, lowering rather than increasing the dose may help: https://www.consumerlab.com/reviews/melatonin-supplements/melatonin/#loss-of-response-to-melatonin
Ava9905
October 01, 2023I was traveling in Scotland and went to the pharmacy to see if they had something not common in the US. I did find a natural oil that helps. BUT what I was surprised to learn is that no product with melatonin in it can be purchased without a doctor’s prescription. Quite a contrast to commercials here extolling melatonin supplements.
Mat9903
November 25, 2023Melatonin seems to be pushed way too much at much higher doses than is necessary by some supplement manufacturers.
See the ConsumerTips section of our Melatonin Supplements Review for information about the best way to take melatonin, including dosage https://www.consumerlab.com/reviews/melatonin-supplements/melatonin/#using.
Alan21708
January 22, 2025I switched to time-release Melatonin pills and that made an enormous and sustained difference in how long I slept.
Regular Melatonin helped me get to sleep earlier, whether 2 mg or 5 mg, but I often woke very early the next morning (3:00 to 5:00 am) and could not get back to sleep. Time-release keeps me asleep for longer periods during the night, and I wake up alert at a decent hour (after 6:00 am).
I am using a 5 mg time-release pill, but I see that Natrol makes a 3 mg version.
Reply to this post…
Maureen9900
May 23, 2023Have there been any studies on GABA supplements for insomnia? Pros and cons?
Please see the "Insomnia" section of our GABA Supplements Review for information https://www.consumerlab.com/reviews/gamma-aminobutyric-acid-gaba-supplements-review/gaba/#insomnia.
Reply to this post…
DANIEL WAGNER MD
May 21, 2023This comment by an MD sleep specialist for 40+ years. Expanding on lifestyle modifications that may help with insomnia. First and foremost is the crucial importance of keeping a regular schedule no matter how well you sleep. Regular means regular i.e. at the very same time 7 days a week without exception. Another aspect is bedtime which should also be highly regular. Amount of time spent in bed is also important. Sleep is segmented and comes apart at its' seams if too much time in bed. Hence the regular schedule should limit the time in bed to your estimated average amount of sleep plus 30 minutes. Would not go below 6 hours in bed. Next, sleep in the dark with no TV, radio, cellphone or computer whatsoever. A night light for bathroom visits is OK. As I tell my insomnia patients: the bed is for sleep and sex and nothing else. Never ever look at your clock or watch during the night. Knowing home much time you have left for sleep is totally unnecessary and fosters anxiety which is arousing. Use the clock only as an alarm (set to the chosen time for getting out of bed. Finally, sleep timing is regulated by our body clocks which need to be reset on a daily basis. This is done by light exposure first thing in the morning. If getting up time is before dawn then spend 10 to 15 minutes in the brightest room in the home. If after dawn go outside if you can. Even cloudy days have enough light to reset a body clock. Hope this helps.
Aray
November 12, 2023Thank you for reiterating all these important conditions for getting sleep. Another which I have found vital is the temperature of the room. There has been much research in the news about how temperature dropping in our core triggers sleep. I believe I have also read that warm feet and cool core initiate sleep. Here is one recent study which talks about how our circadian rhythms are tied to temperature,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491889/
Jennifer20920
October 21, 2024Thank you for the information.
Reply to this post…
T Allen
May 16, 2023A TBSP of Chamomile puts me right to sleep but doesn't help with early waking. 1 mg of melatonin doesn't help my sleep much but I'm groggy until noon the next day! CBD helps with pain so if that's the cause of insomnia it helps, otherwise it doesn't.
When taking melatonin, we suggest trying the lowest dose possible that works for you, which for some people may be less than 1 mg (see https://www.consumerlab.com/reviews/melatonin-supplements/melatonin/#using). Also, be aware that while there is some preliminary evidence that CBD may be beneficial in people with difficulty sleeping related to anxiety and certain other disorders, it does not appear to be helpful as a sleep aid in healthy individuals -- see https://www.consumerlab.com/reviews/cbd-oil-hemp-review/cbd-oil/#shannon. There is little quality evidence that CBD is helpful for pain -- see https://www.consumerlab.com/reviews/cbd-oil-hemp-review/cbd-oil/#pain.
Mat9896
May 19, 2023I've tried melatonin for sleep but found I can't tolerate it. I've taken 3 mg and feel like I was kicked in the head the next morning. I think it's important to get your melatonin levels checked for deficiencies before taking.
You may want to consider a lower dose, such as 1 mg. Easily done with a liquid, or opening and partially emptying a capsule.
Vonalda9895
August 20, 2023Also by splitting a chewable pill in half, for example. Much easier than trying to open up and/or partially empty a capsule every time! My favorite Melatonin is Natrol fast dissolve Strawberry (3 mg.) Breaks in half easily and I love the flavor (so, bonus)!
Reply to this post…
Michael9890
March 04, 2023Every insomnia article touts melatonin as a sleep enhancer, and 10-20 mg at night did help my primary sleep maintenance insomnia. However, it very distinctly made me fall several times every day for years. I quit it when research showed that supplemental melatonin doesn't enhance mitochondria or fight cancer, and beginning THE NEXT DAY I haven't fallen ONCE in six months. Granted, my vestibular system is independently impaired, but going overnight from falling a few times every day to not once in 6 months is life-changing. Melatonin users who fall should consider going without it for a few days as a trial.
The amount of melatonin you were taking was much higher than indicated to help with sleep and could have caused impairment the next day, as you describe. A lower dose would be less likely to have had that effect.
Linda22827
May 23, 2025My daughter and I both take 20 mg. time released. No bad side effects. No next day drowsiness, no falls. Just better sleep!
Please note that is a very high dose for melatonin, especially if you’re taking it regularly. Typically, lower doses are used and recommended, as we discuss in our Melatonin Review https://www.consumerlab.com/reviews/melatonin-supplements/melatonin/#dosage.
Reply to this post…
Pat9887
November 19, 2022I'm wondering how many people experience vivid dreams or nightmares after drinking chamomile tea. For me this effect became so bothersome that I had to give up my Sleepytime tea habit. I know it's the chamomile because having straight chamomile tea gave me nightmares consistently. I've since spoken with other people who had a similar experience but can't find much online.
I have no financial interest in any sort of sleep product. Exercise during the day and avoiding caffeine have helped me the most.
Boris9888
March 05, 2023Are you sensitive to FODMAPs by chance? I tend to have nightmares if I have FODMAPs close to bedtime and chamomile tea is very high in those (fructans, specifically).
John9889
August 20, 2023I have found that Valerian tea actually works with no side effects. I know this may seem anecdotal but for me it has been a godsend. Melatonin makes me groggy the next day and Valerian tea is my answer!
Reply to this post…
Stan9885
November 12, 2022PREGNANCY & CHAMOMILE: Please note studies that chamomile tea is to be avoided during pregnanct due to an increased potential of miscarrriage and bleeding. I would assume that chamomile in other forms would pose the same or greater potential risks during pregnancy.
Thanks for bringing this to our attention. We've added a caution statement about concerns related to the use of chamomile during pregnancy in the article above.
Reply to this post…
Toni9882
November 02, 2022Falling asleep has been my issue (until recently). I suspect that once I did finally go to sleep, it was not a deep restorative sleep. I felt tired and sleepy during the day and craved 3-4 hour naps in the afternoon, which I’m sure just compounded my problem at night. I’d tried just about everything (short of sleep medication)… glycine, melatonin, L-Theanine, magnesium, sleepy time tea, sound machine, and the list goes on….nothing helped. Until I found a combination of many of the natural supplements I tried in a product on Amazon called ‘NightRest’ (Source Naturals Sleep Science NightRest With MelatoninMultiNutrient & Herb Complex). Two (2) tablets 30 minutes before bed and I am falling asleep quickly. Finally getting the deep, restful sleep that my body has been craving. The first couple of weeks after starting it I still needed to take those afternoon naps… assuming my body was catching up from being sleep deprived. The 3rd week in, I no longer required 3-4 hour naps during the day. I cannot say enough about this product. I receive no financial remuneration for this recommendation. I am 71 years old and am only reporting my experience with this product. Your results may differ…and of course, always check with your doctor before adding any supplement to your regime.
Judith9883
December 23, 2022Does it put you in the deep sleep phase? My Apple Watch and iPhone app tell me I very seldom in that phase.
Lona9884
March 03, 2023Have you been tested for sleep apnea?
Reply to this post…
Wallie9880
October 11, 2022thank you for sharing your detailed information Robert Yes, we all need help regarding our sleep problems. I will try some of your suggestions and hope my sleep habits will improve.
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Diane9877
September 30, 2022If wake in the middle of the night and can't get back to sleep I drink a cup of organic Chamomile tea and within 10 to 15 minutes I am asleep for the rest of the night. Only thing that works for me.
Reply to this post…
Nancy9873
August 15, 2022Over the counter progesterone cream was a life saver for me. I can’t sleep without using it on a regular basis. A doctor recommended it.
gm
October 11, 2022thanks what over the counter progesterone to you recommend
Nancy Y
March 29, 2025Pro-gest by Emerita eliminated my PMS completely at the time and then helped with hot flashes during menopause (along with the estrogen bioidentical cream). Now I’ve started using it again for sleep. The cycle of life I guess ;)
It’s expensive but lasts maybe 6-9 months for me because I only use a dab. I put it on the inside of my wrists. I have no vested interest in the product, just wanted to share.
Reply to this post…
Toni9872
August 14, 2022I found that taking my magnesium at bedtime and taking my vitamin B in the morning greatly improved my ability to fall asleep and now I dream much more.
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Steven9869
July 26, 2022Cannabis works best for insomnia for me. 5Mg THC Indica edible containing CBN or CBD works best
liveto94
July 28, 2022I am presently using camomile. I make the tea with a tea bag (organic) and add a dropper full of good quality tincture (organic). I use a little bit of stevia to sweeten it. I find that it help me fall asleep. I wake about 4-5 hours later and am wide awake. I have another cup ready (made earlier when I make the 1st cup and by the middle of the night the second cup is at room temp wc is okay with me). I drink it and I can go back to sleep. That said, it does give me nightmares at times. But I have to choose. I have so much trouble sleeping and this camomile helps me sleep so I have put up with the nightmares. I cannot tolerate any other sleep aid. including not any of the sleep herbs. They all do the opposite or don't work at all.
Reply to this post…
Barbara9864
July 26, 2022I've tried many things. The very best is CBD oil before bed & again if you wake up during the night.
Charles9868
July 29, 2022Yeah, I have found the CDB oil about an hour before bedtime does, in fact, make it easier to fall asleep. I was skeptical at first but I'm now convinced it works, at least for me.
Lisa9867
August 09, 2022I have found CBD oil to be effective, but am concerned that it may have a harmful interaction with my thyroid medication.(levothyrixine).
We've added information about this in our article about supplement interactions with levothyroxine https://www.consumerlab.com/answers/do-any-supplements-interfere-with-thyroid-hormones/hypothyroidism-and-supplements/#cb.
Reply to this post…
tborcl
April 12, 2022In a quest for a deep, full night of sleep I've tried most of the products mentioned in the article.
Currently I'm having success with glycine (an amino acid in protein) and l-theanine. Glycine helps me fall and stay asleep and l-theanine calms my mind for deep sleep.
My dosage: Glycine 3 mg plus l-theanine 200 mg, both a half hour before bed. If I happen to wake in the middle of night and can't fall back asleep I'll take an additional 1mg of glycine and 100 mg of l-theanine. (If you try these your dosage and success may very of course.)
Other things I do to help my sleep:
I avoid all caffeine, even in the morning. Even decaf coffee has a little bit of caffeine in it. As does chocolate. I take any supplements that might energize me, like my multivitamin or Coq10, in the morning.
In addition I dim all lights an hour or more before bed and try not to use my phone or computer. If I watch TV I dim the backlight it to the lowest setting.
I installed room darkening shades and curtains so my bedroom is very dark. Also for any gadget in the room that has a bright LED on it (like a Roku for example), I covered the LED with black electrical tape.
And although I can't do it everyday, I definitely sleep better on the days in which I work out or do a lot of walking.
My results with other supplements:
Valerian - Gives deeper sleep once sleeping, but doesn't put me to sleep. Doesn't always give me a full nights sleep. If I wake up in the middle of night, more valerian does not put me back to sleep.
5-HTP - Puts me to sleep and gives good sleep but often times I get grogginess in morning. Interestingly, it reduces my sleep apnea incidents (as measured by my CPAP machine.)
L-Tryptophan - Puts me to sleep but sometimes I would wake up in middle of night and had trouble getting get back to sleep.
Melatonin - I've tried regular and timed release versions. It worked well at first but my body quickly built up a tolerance and the pills lose their effectiveness after several days.
Magnesium - Doesn't put me to sleep, but once asleep it helps give deeper sleep. However I assume because it relaxes my muscles, my sleep apnea increases when I take magnesium before bed.
Benadryl / diphenhydramine / ZZZQuil (allergy pill / sleep aid) - Although this helps me sleep it causes grogginess in the morning. Also it is anticholinergic, which is not good for the brain, so I will not use this at all anymore.
Hope all this helps someone!
Milia9863
June 23, 2022I can't thank you enough for taking the time to share this information with us!! Sounds like you and I are pretty similar in our quest for a decent night's sleep ??! I haven't heard of some of the things you suggested, so I will definitely try them, although I realize I might not have the same results as you did. They're certainly worth a try, though! I'm guessing that my insomnia is at least due partly to my up-and-down hormones (I'm 54), so that complicates things. But I am so very appreciative of your suggestions ??!!
Carol9862
August 09, 2022Thank you, Robert, for taking the time to share what works for you!
tborcl
August 09, 2022Correction: I meant to say I take 3 grams of glycine (not 3 milligrams) before bed and an additional 1 gram (not 1 milligram) in the middle of night if needed.
Also an update: I ran out of glycine and have been trying magnesium glycinate instead. It seems to work as well as plain glycine. I take 240 mg of magnesium glycinate before bed, and if I happen to wake up in the middle of the night I'll take an additional 120 mg. Again, your dosage may vary. Also check with your doctor before you use it, or for that matter any other items I've mentioned. Sleep well.
Jose9858
August 15, 2022Thank you for your explanation and results in you body.
A good suggestions. I will try after my holidays.
Carol20663
September 17, 2024yes-- I echo thanks for posting your experience
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john9856
March 11, 2022I get insomnia from most herbal supplements I take. Betaine Hcl taken with my supplements has helped a little bit. Of course I take all supplements in the early am. I am 83 years old . Any help would be appreciated.
Dr John Mohney DO
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Pam9853
June 14, 2020Vitamin K can cause insomnia. Especially K2. I had to stop taking it as it really made me uptight and anxious.
Thank you for sharing this. As noted above, vitamin K is not generally known to cause insomnia and we are not aware of any published reports of this.
tony9854
March 08, 2022I also struggled to sleep after taking MK-7. Kept me wide awake all night. It was a horrible experiment and experience. I plan on trying MK-4 since I hear it might be less problematical and has a shorter half life. I am confused about eating cheese to get the K2 since some studies report dairy contributes to heart disease and other studies say dairy prevents heart disease.
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Daniel9849
May 27, 2019In the past I read that eating protein later in the day might contribute to sleeplessness, for what it's worth.
tony9850
March 08, 2022Funny my doctor says eating protein like cheese late in day and evening encourages sleep
Mat9851
August 01, 2022This may (partly) be due to protein making you feel full and being easily digested, as opposed to carbohydrates ?
Reply to this post…
Alexandra9844
March 06, 2019Hi, i’ve had terrible insomnia since taking berberine, but everywhere that I have researched it doesn’t say there is any link between insomnia and berberine, can you please let me know if you’ve heard of this before? Thanks
Hi Alexandra - There do not appear to be any reports of insomnia as a side effect of berberine supplementation. You can find more information about berberine side effects in the "Cautions and Concerns" section of the Berberine and Goldenseal Supplements Review: https://www.consumerlab.com/reviews/berberine-goldenseal-supplements-review/berberine/#cautions
Lu9846
March 12, 2022I experienced insomnia after taking Oregon Grape right before bed so I think berberine's impact on sleep warrants additional study
Reply to this post…
Sigrid9842
February 27, 2019Why is there never any information and warning about the high amounts of glutamate in protein powders and chelated supplements ? Our bodies are getting an overload of glutamate anyway, because it is hidden under so many different names in the food supply. I have ended up in the E.R. several times with severe side-effects like tachycardia, hyper-excitability, digestive problems and sensory changes in my arms and legs. I also can not fall asleep because I am so hyper. But when my diet is void of added sources of concentrated glutamate, I sleep like a baby.
See a listing of all the sources on a site like ' Hidden sources of MSG ,Truth in labeling campaign'. Reading it has changed my life and health for the better dramatically.
We all have a different threshold -I am extremely sensitive to it-, but at a certain level everybody will have a reaction .
S.F.M
Richard9843
March 12, 2022I once took an L-glutamate tab on an empty stomach (in the morning)...not advised.
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Stephen9840
June 20, 2018What is considered to be a 'high amount''?
Hi Stephen - If you click on "Concerns and Cautions" link in the Answer it will take you to the section in the the Vitamin D Review that provides more detail ( https://www.consumerlab.com/reviews/vitamin-d-supplements-review/vitamin-d/#melatonin).
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Linda9835
February 22, 2018For Tim & Joe-
What are the dosages for the 3 items you take and the timing? I too have interrupted sleep and wake at that "witching" hour of 3a. Thank you - Linda
T Allen
August 02, 2022Linda, Google "histamine 3am wake up" I have MCAS and taking an H1 blocker before bed as well as a low histamine diet helps.
Veena9836
August 23, 2022HI I have MCAS too. What helps you with falling and staying asleep?
Veena9838
April 11, 2023Thanks.
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Tim and Joe9832
February 21, 2018I have had bad insomnia for several years (fall asleep no problem, but wake up at 3-3:30 am every morning). I too take vitamin D as I have an extreme deficiency. It will not hurt for you to try cutting out supplements to try and determine if one of them are affecting your sleep, but understand that our bodies change as we age, and there are side effects of these changes, and the answer may not be as simple as you hope. I have been on my quest for optimal sleep for five years now. I have learned a LOT about sleep, and more importantly all of the different bodily cycles responsible for sleep. It is odd that something so common - that we all MUST do - is so complicated and so heavily regulated by our bodies. Long story short, after trying EVERYTHING, it was determined that my Serotonin / Cortisol cycle was out of whack. For me, my deficiency in Vitamin D exacerbated the problem, and far from causing insomnia in me, I needed vitamin D for sleep. In the end, I take melatonin, tryptophan, and 5-HTP, and I now average 7 hours sleep per night. On those days where I wake at 3 am with the cortisol raging, I pop an additional 100mg 5-HTP and within a half hour I am back to sleep until 7-7:30
I guess what I am saying is that you are looking for a simple answer to a complex problem, and unfortunately, our bodies do not work that way. What works for one person, may not work for you, because the underlying problem may be very different, yet with the exact same result - lack of sleep.
Hi Tim and Joe - We are currently testing 5-HTP and tryptophan supplements and expect to publish a report this year. In the meantime, you may also find our review article on these supplements helpful: https://www.consumerlab.com/reviews/l-tryptophan-5-htp/tryptophan/.
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John9830
February 20, 2018I am unable to sleep when I take a multivitamin pill, even a childrens version, and over the years discovered I was extremely sensitive specifically to Vitamin E. Same for taking a vitamin D supplement. I can take a large dose (5 - 10,000 iu) of D once a week, but even a small dose (1000 iu) daily gives me insomnia. I learned that I am sensitive to all 4 oil soluble vitamins if taken in a dose even approaching 50% of the RDA. I think the problem could have to do with metabolism. Possibly a coincidence but I also have celiac sprue.
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robert9827
February 18, 2018interested in comment about insomnia and vitamin d.
i have insomnia and take D3 (1000iu) plus my multi vitamin contains another 500iu.
interested in research on this subject.
can you refer to me this research as i could not locate anything about INSOMNIA / VIT. D
thanks
Hi Robert - Please use the link to the "Concerns and Cautions" section of the Vitamin D Supplements Review in the answer -- this section provides more details and the research on this.
luba9828
January 03, 2019I, too, suffered from insomnia when taking Vitamin D. I switched to AOR 'liquid' Vitamin D, taking it with my morning tea with a spot of cream. Within days, sleep improved.
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