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Omeprazole (Prilosec), Nexium, and other proton pump inhibitor (PPI) drugs can be affected by taking supplements. St. John's wort, for example, should not be taken with these drugs.

PPIs can affect your ability to absorb certain vitamins and minerals, such as reducing calcium absorption. See our Calcium Supplements Review to learn how to minimize the effect of PPIs on the absorption of calcium from supplements.

Be sure to also read about magnesium depletion, which can occur with PPI use, in the Magnesium Supplements Review.

Also see our CL Answer about supplements for indigestion and heartburn.

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