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Choline and Lecithin Supplements Review (Including Phosphatidylcholine, CDP-Choline, and Alpha-GPC)

Choose the Best Choline Supplement. Find Out How Much Choline Popular Supplements Really Provide.

Latest Update

Eggs for Alzheimer’s

Medically reviewed and edited by Tod Cooperman, M.D.

Updated February 21, 2025 ⓘ

Products tested in 2021, 2022 and 2025

+— 57 sources

In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:

Summary

What is choline?
Choline is is an essential nutrient. It is a component of cell membranes and the neurotransmitter acetylcholine, which is essential for proper brain function, and it helps remove fat from the liver (see What It Is). The body naturally produces some choline and the rest can be obtained from the diet, but some people are not able to produce sufficient choline, particularly postmenopausal women and people with certain genetic traits, putting them at risk for choline deficiency. In addition, women need extra choline when pregnant or nursing.
What does choline do?
Getting adequate choline from the diet helps prevent fatty liver (which can lead to reduced liver function) and muscle damage. During pregnancy, choline taken by women may reduce the risk of birth defects, and supplementation was even shown to improve infants' intellectual processing speeds. Supplemental choline has shown potential benefit with respect to stroke recovery, cognition, Alzheimer's disease, asthma, and ulcerative colitis (see What It Does).
How to get choline?
Many foods are good sources of choline, particularly egg yolks, meats, and legumes (see Getting It from Food). Lecithin, typically extracted from raw soybean or sunflower seed oils, is also a convenient food source of choline due to the phosphatidylcholine that it contains. (Lecithin is also a source of phosphatidylserine, which we have reviewed separately.) Supplements can also provide choline in a variety of forms, including phosphatidylcholine, alpha-GPC, CDP-choline (citicoline), choline bitartrate, and choline citrate. We purchased and tested products containing each of these forms.
Which form of choline is best?
A problem when choosing a choline supplement is that the different forms provide vastly different amounts of choline — and these differences are not clearly labeled. (See Comparison of Choline Ingredients in Supplements). To avoid confusion, we've calculated and shown the amounts of choline expected from the products we tested — as well as whether or not they contained these amounts (see the Results Table.
How much choline should I take?
Adequate daily intake of choline ranges from 200 mg to 550 mg depending on the person (see (see Recommended Intake), but many people get too little. The typical dose used in disease treatment ranges from 50 mg to several thousand milligrams daily of specific forms of choline (see Dosage). We found as little as 19.4 mg to as much as 500 mg of choline per serving in the supplements that we tested.
Best choline supplement?
Most, but not all, products passed our tests of quality (see What CL Found and How Products Were Evaluated), but only a few represent CL's Top Picks. We also chose an overall Top Pick that provides a form of choline that may be safer and better absorbed than others and is also relatively low cost. We found that you could pay as little at 2 cents to as much as 58 cents to get an equivalent 100 mg dose of choline from supplements.
Safety and side effects of choline:
Choline is generally safe, although gastrointestinal side effects may occur with higher doses. A small percentage of people may develop a fishy body odor from choline. Although cause-and-effect relationships have not been demonstrated, higher intake of choline has been associated with increased risk of colorectal cancer in women, and some forms of choline increase production of TMAO, which, itself, is associated with a higher risk of heart attack. (See Concerns and Cautions).

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Choline supplements compared in this review

Bestvite Cognizin

Double Wood Alpha-GPC 300 mg

GNC Choline

InnovixLabs Choline

Legendairy Milk Sunflower Lecithin

Natural Factors Phosphatidyl Choline (PC) 420 mg

NOW Lecithin 1,200 mg

NOW Sunflower Liquid Lecithin

Nutricost CDP Choline

Nuts.com Soy Lecithin Powder

Perque Choline Citrate

Puritan's Pride Concentrated Ultra Lecithin 1,200 mg

Solgar Choline/ Inositol 500 mg/ 500 mg

Solgar Phosphatidyl Choline

Swanson Alpha-GPC

Vitacost Choline & Inositol

You must be a member to get the full test results along with ConsumerLab.com recommendations and quality ratings. You will get results for 11 choline-containing supplements selected by ConsumerLab.com and for five others that passed testing through our voluntary Quality Certification Program. In this comprehensive review, you'll discover:

Which choline supplements passed our tests and which did not
ConsumerLab.com's Top Picks, representing the best quality choline supplements at the best price
Differences among forms of choline, including phosphatidylcholine (from lecithin), CDP-choline, citicoline, Cognizin, choline citrate, Alpha-GPC, choline alfoscerate and choline bitartrate

The evidence behind the health benefits of choline
How to buy and use choline supplements
How to get choline from foods
Choline's side effects, cautions, and particular concerns with choline bitartrate