uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.


St John's Wort Supplements Reviewed By


  • Do St. John's wort supplements help?

    Taking a supplement with the right type and amount of St. John's wort extract appears to be as effective in treating major depression of mild to moderate severity as standard antidepressant drugs, but with fewer side effects. St. John's wort is unlikely to help people who aren't truly depressed (See What It Does).
  • How much St. John's wort should I take?

    Clinical trials suggest that an effective dose is 900 mg per day of a concentrated extract standardized to at least 0.3% hypericin and/or 1% to 3% hyperforin (see ConsumerTips™).
  • Which St. John's wort product is best?

    Choose carefully, because 60% of the St. John's wort supplements selected for testing by did not contain expected amounts of one or more key plant chemicals. There was enormous range in these amounts, indicating that you could get, for example, as much as 280 times more hyperforin from one product than from another. Four products were Approved by, three of which are good choices and one of which was CL's Top Pick. Use our Results Table to see which products were, or were not, Approved, and to compare ingredients, test results, and prices.
  • Don't get hurt! Safety and side effects of St. John's wort:

    Although generally safe, St. John's wort can cause a range of side effects. It may cause mania in people with bipolar disorder and it may increase sensitivity to ultraviolet light, causing unexpected sunburn. Most importantly, St. John's wort can interact with a wide range of medications. See Concerns and Cautions for more information.

Make sure you're choosing the best St. John's wort supplements approved in our tests!

See the Full Review as a Member

Join now at

Alphabetical list of St. John's wort supplement brands compared in this review

View Larger Image GaiaHerbs-StJohnsWort-Small-2016.jpg

Gaia Herbs St. John’s Wort Flower Buds & Tops

View Larger Image NaturesWay-Perika-StJohnsWort-Small-2016.jpg

Nature's Way Perika St. John's Wort

View Larger Image NOW-StJohnsWort-Small-2016.jpg

NOW St. John's Wort

View Larger Image PlanetaryHerbals-StJohnsWort-Small-2016.jpg

Planetary Herbals Full Spectrum St. John’s Wort

View Larger Image Shaklee-StJohnsWort-Small-2016.jpg

Shaklee MoodLift Complex

View Larger Image StandardProcess-StJohnsWort-Small-2016.jpg

Standard Process MediHerb St. John's Wort

View Larger Image Swanson-StJohnsWort-Small-2016.jpg

Swanson St. John's Wort

View Larger Image Vitacost-StJohnsWort-Small-2016.jpg

Vitacost St. John's Wort Extract

View Larger Image TheVitaminShoppe-StJohnsWort-Small-2016.jpg

Vitamin Shoppe St. John's Wort Extract

View Larger Image WholeFoods-StJohnsWort-Small-2016.jpg

Whole Foods St. John's Wort

You must be a member to get the full test results and independent quality ratings for St. John's wort supplements along with's recommendations of the best St. John's wort supplements. In this comprehensive review, you'll discover:

  • Which St. John's wort supplements failed testing, which passed, and which one is's Top Pick
  • Key differences in quality and ingredients among St. John's wort supplements
  • Which supplements are most like clinically-tested St. John's wort extract 
  • Price comparisons of St. John's wort supplements to help you find the best quality St. John's wort at lowest cost
  • Dosage recommendations for the antidepressant use of St. John's wort extracts and other herbal preparations
  • Concerns, cautions, side-effects and many drug interactions to avoid with St. John's wort

Join to unlock the full report and get full access to over 1,400 reviews

See the Full Review as a Member

Join now at

Additional Information
Tested through CL's Quality Certification Program prior to, or after initial posting of this Product Review.