A peptic ulcer is a sore in the lining of the stomach or the small intestine caused by long-term irritation due to Helicobacter pylori (H. pylori) infection or regular use of nonsteroidal anti-inflammatory drugs (NSAIDs). Peptic ulcers caused by H. pylori infection are typically treated with antibiotics. Supplements such as probiotics, cranberry, melatonin, lactoferrin, berberine, and licorice may possibly be beneficial in H. pylori eradication or reducing the side effects of antibiotics used to treat H. pylori infection. Mastic gum and honey do not seem to help. Arginine, feverfew, and iron might worsen symptoms. Sign in and read the full answer for more information and details.