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Genetic Testing for Age-Related Macular Degeneration (AMD) Supplements
Question: My optometrist recommended genetic testing to determine the effectiveness of various supplements for AMD. What is the evidence for doing this?
Answer: As described in the Vision Supplements Review, certain genetic variations , or polymorphisms (more details about the specific genes are found in the Review), are associated with higher or lower risk of developing age-related macular degeneration (AMD). These variations, in turn, have been associated with better or worse outcomes from supplementation with antioxidants and zinc known to generally reduce the progression of AMD. However, as explained in the Vision Supplements Review, it has yet to be proven that genetic testing will result in a better outcome in guiding the use of supplements for treating AMD, so it seems premature to rely on these tests to determine supplementation.